ChemicalBook >> CAS DataBase List >>MC-Val-Cit-PAB
MC-Val-Cit-PAB
- CAS No.
- 159857-80-4
- Chemical Name:
- MC-Val-Cit-PAB
- Synonyms
- N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide;MC-Val-Cit-PAB-OH;EOS-60616;MC-Val-it-PAB;ML-Val-Cit-PAB;MC-Val-Cit-PAB;MC-Val-Cit-PAB/MC-VC-PAB-OH;Benzenemethanol,2-chloro-8-nitro-;MC-Val-Cit-PAB (ADC peptide linker)
- CBNumber:
- CB02554361
- Molecular Formula:
- C28H40N6O7
- Molecular Weight:
- 572.65
- MDL Number:
- MFCD26142966
- MOL File:
- 159857-80-4.mol
- MSDS File:
- SDS
Last updated:2024-03-29 18:52:01
Boiling point | 931.6±65.0 °C(Predicted) |
---|---|
Density | 1.276 |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | DMSO: soluble |
form | powder to crystal |
pka | 13.41±0.70(Predicted) |
color | White to Almost white |
InChIKey | UMDCMQHPXQLHGR-OFVILXPXSA-N |
SMILES | C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(CO)C=C1 |
CAS DataBase Reference | 159857-80-4 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
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MC-Val-Cit-PAB price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | M3224 | MC-Val-Cit-PAB-OH | 159857-80-4 | 100MG | $281 | 2024-03-01 | Buy |
TCI Chemical | M3224 | MC-Val-Cit-PAB-OH | 159857-80-4 | 500MG | $845 | 2024-03-01 | Buy |
Cayman Chemical | 28285 | Mc-Val-Cit-PAB | 159857-80-4 | 5mg | $100 | 2024-03-01 | Buy |
Cayman Chemical | 28285 | Mc-Val-Cit-PAB | 159857-80-4 | 50mg | $739 | 2024-03-01 | Buy |
Cayman Chemical | 28285 | Mc-Val-Cit-PAB | 159857-80-4 | 1mg | $34 | 2024-03-01 | Buy |
MC-Val-Cit-PAB Chemical Properties,Uses,Production
Description
MC-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit was designed to be cleaved specifically by Cathepsin B. MC group is reactive with thiol moiety
Uses
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide is used as a reagent to prepare antibody-drug conjugates, which are compounds that selectively deliver cytotoxic drugs to a tumour-associated antigen.
MC-Val-Cit-PAB Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
Global( 188)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ChemExpress | +86-021-58950125 +86-021-58950125; | info@chemexpress.com | China | 598 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10312 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19343 | 58 |
Jurong Coupling Biotechnology Co., Ltd. | 13656108824 | coupling278191416@hotmail.com | CHINA | 184 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
View Lastest Price from MC-Val-Cit-PAB manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-03-29 | MC-Val-Cit-PAB-OH
159857-80-4
|
US $0.00 / g | 1g | >98.00% | 1g | Xian confluore Biological Technology Co., Ltd. | |
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2020-01-09 | N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
159857-80-4
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- MC-Val-Cit-PAB-OH
159857-80-4
- US $0.00 / g
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
-
- N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
159857-80-4
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co
159857-80-4(MC-Val-Cit-PAB)Related Search:
L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-(hydroxyMethyl)phenyl]-
ML-Val-Cit-PAB
MC-Val-Cit-PAB, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
MC-Val-Cit-PAB
MC-Val-it-PAB
N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide
EOS-60616
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymeth
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureidopentan-2-yl]amino]-3-methyl-1-ox
6-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureido-2-pentyl]amino]-3-methyl-1-oxo-2-butyl]hexanamide
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide
MC-Val-Cit-PAB-OH
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N2-[4-(hydroxymethyl)phenyl]-L-ornithinamide
Benzenemethanol,2-chloro-8-nitro-
MC-Val-Cit-PAB (ADC peptide linker)
6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-1-[[(1S)-1-[[4-(hydroxymethyl)phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]hexanamide
MC-Val-Cit-PAB/MC-VC-PAB-OH
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N2-[4-(hydroxymethyl)phenyl]-L-ornithinamide
159857-80-4
59857-80-4
C28H40N6O7
ADCs
ADC Linker
ADC-Linker
ADC-Linkers