MC-Val-Cit-PAB
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MC-Val-Cit-PAB 속성
- 끓는 점
- 931.6±65.0 °C(Predicted)
- 밀도
- 1.276
- 저장 조건
- under inert gas (nitrogen or Argon) at 2-8°C
- 용해도
- DMSO: 용해될 수 있다
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 13.41±0.70(Predicted)
- 색상
- 흰색에서 거의 흰색
- InChIKey
- UMDCMQHPXQLHGR-OFVILXPXSA-N
- SMILES
- C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(CO)C=C1
- CAS 데이터베이스
- 159857-80-4
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
MC-Val-Cit-PAB C화학적 특성, 용도, 생산
용도
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide is used as a reagent to prepare antibody-drug conjugates, which are compounds that selectively deliver cytotoxic drugs to a tumour-associated antigen.주요 응용
MC-Val-Cit-PAB is a peptide linker that can be used to prepare antibody-drug conjugates (ADCs) for cancer therapy research. For example, CBP-1018, a dual-ligand PDC, is conjugated to MMAE via a cleavable linker (MC-Val-Cit-PABC) that can be cleaved by proteinase B[1]. MC-Val-Cit-PAB can also be used to prepare cetuximab-vc-DOX-NPs conjugates, which have good tumor targeting ability and low systemic toxicity, and are a promising drug delivery targeting system[2].MC-Val-Cit-PAB 준비 용품 및 원자재
원자재
N-Succinimidyl 6-maleimidohexanoate
4-Aminobenzyl alcohol
발-시트-PAB-OH
6-Maleimidocaproic acid-PFP ester
H-Cit-PABA
3-말레이미도-프록실
FMOC-L-Valine
시트룰린
L-오르니틴,N5-(a미노카르보닐)-N2-[N-[(9H-플루오렌-9-일메톡시)카르보닐]-L-발릴]-
FMOC-VAL-OSU
FMoc-발-Cit-PAB
6-아미노 카프로산
준비 용품
MC-Val-Cit-PAB 공급 업체
글로벌( 189)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ChemExpress | +86-021-58950125 +86-021-58950125; |
info@chemexpress.com | China | 738 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32951 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10310 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 17254 | 58 |
| Jurong Coupling Biotechnology Co., Ltd. | 13656108824 |
coupling278191416@hotmail.com | CHINA | 184 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29811 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32079 | 58 |