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MC-Val-Cit-PAB

MC-Val-Cit-PAB Structure
MC-Val-Cit-PAB structure
CAS No.
159857-80-4
Chemical Name:
MC-Val-Cit-PAB
Synonyms
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide;MC-Val-Cit-PAB-OH;EOS-60616;MC-Val-it-PAB;ML-Val-Cit-PAB;MC-Val-Cit-PAB;MC-Val-Cit-PAB/MC-VC-PAB-OH;Benzenemethanol,2-chloro-8-nitro-;MC-Val-Cit-PAB (ADC peptide linker)
CBNumber:
CB02554361
Molecular Formula:
C28H40N6O7
Molecular Weight:
572.65
MDL Number:
MFCD26142966
MOL File:
159857-80-4.mol
MSDS File:
SDS
Last updated:2024-11-20 11:41:24
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MC-Val-Cit-PAB Properties

Boiling point 931.6±65.0 °C(Predicted)
Density 1.276
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO: soluble
form powder to crystal
pka 13.41±0.70(Predicted)
color White to Almost white
InChIKey UMDCMQHPXQLHGR-OFVILXPXSA-N
SMILES C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(CO)C=C1
CAS DataBase Reference 159857-80-4

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

MC-Val-Cit-PAB price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical M3224 MC-Val-Cit-PAB-OH 159857-80-4 100MG $281 2024-03-01 Buy
TCI Chemical M3224 MC-Val-Cit-PAB-OH 159857-80-4 500MG $845 2024-03-01 Buy
Cayman Chemical 28285 Mc-Val-Cit-PAB 159857-80-4 5mg $100 2024-03-01 Buy
Cayman Chemical 28285 Mc-Val-Cit-PAB 159857-80-4 50mg $739 2024-03-01 Buy
Cayman Chemical 28285 Mc-Val-Cit-PAB 159857-80-4 1mg $34 2024-03-01 Buy
Product number Packaging Price Buy
M3224 100MG $281 Buy
M3224 500MG $845 Buy
28285 5mg $100 Buy
28285 50mg $739 Buy
28285 1mg $34 Buy

MC-Val-Cit-PAB Chemical Properties,Uses,Production

Description

MC-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit was designed to be cleaved specifically by Cathepsin B. MC group is reactive with thiol moiety

Uses

N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide is used as a reagent to prepare antibody-drug conjugates, which are compounds that selectively deliver cytotoxic drugs to a tumour-associated antigen.

Application

MC-Val-Cit-PAB is a peptide linker that can be used to prepare antibody-drug conjugates (ADCs) for cancer therapy research. For example, CBP-1018, a dual-ligand PDC, is conjugated to MMAE via a cleavable linker (MC-Val-Cit-PABC) that can be cleaved by proteinase B[1]. MC-Val-Cit-PAB can also be used to prepare cetuximab-vc-DOX-NPs conjugates, which have good tumor targeting ability and low systemic toxicity, and are a promising drug delivery targeting system[2].

References

[1] LC-MS/MS method for dual-ligand peptide-drug CBP-1018 and its deconjugated payload MMAE including sample stabilization strategy for its MC-Val-Cit-PABC linker[J]. Talanta, 2024. DOI:10.1016/j.talanta.2024.126596.
[2] ZIXUAN YE. EGFR Targeted Cetuximab-Valine-Citrulline (vc)-Doxorubicin Immunoconjugates- Loaded Bovine Serum Albumin (BSA) Nanoparticles for Colorectal Tumor Therapy.[J]. International Journal of Nanomedicine, 2021. DOI:10.2147/IJN.S289228.

MC-Val-Cit-PAB synthesis

55750-63-5
159857-79-1
159857-80-4
Synthesis of MC-Val-Cit-PAB from N-Succinimidyl 6-maleimidohexanoate and Val-cit-PAB-OH

MC-Val-Cit-PAB Preparation Products And Raw materials

Raw materials

N-Succinimidyl 6-maleimidohexanoate 4-Aminobenzyl alcohol Val-cit-PAB-OH 6-Maleimidocaproic acid-PFP ester H-Cit-PABA
6-Maleimidocaproic acid FMOC-L-Valine L-Citrulline Fmoc-Val-Cit-OH FMOC-VAL-OSU
FMoc-Val-Cit-PAB 6-Aminocaproic acid

1of3

Preparation Products

Mc-Val-Cit-PABC-PNP

MC-Val-Cit-PAB Suppliers

Global( 191)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemExpress
+86-021-58950125 +86-021-58950125; info@chemexpress.com China 781 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32956 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10311 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 17777 58
Jurong Coupling Biotechnology Co., Ltd. 		13656108824 coupling278191416@hotmail.com CHINA 184 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Supplier Advantage
ChemExpress
58
ATK CHEMICAL COMPANY LIMITED 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Jurong Coupling Biotechnology Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from MC-Val-Cit-PAB manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MC-Val-Cit-PAB pictures 2024-11-19 MC-Val-Cit-PAB
159857-80-4
 US $0.00-30.00 / mg 98.24% 10g TargetMol Chemicals Inc.
MC-Val-Cit-PAB-OH pictures 2024-03-29 MC-Val-Cit-PAB-OH
159857-80-4
 US $0.00 / g 1g >98.00% 1g Xian confluore Biological Technology Co., Ltd.
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide pictures 2020-01-09 N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
159857-80-4
 US $6.68 / KG 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co
  • MC-Val-Cit-PAB pictures
  • MC-Val-Cit-PAB
    159857-80-4
  • US $0.00-30.00 / mg
  • 98.24%
  • TargetMol Chemicals Inc.
  • MC-Val-Cit-PAB-OH pictures
  • MC-Val-Cit-PAB-OH
    159857-80-4
  • US $0.00 / g
  • >98.00%
  • Xian confluore Biological Technology Co., Ltd.

MC-Val-Cit-PAB Spectrum

MC-Val-Cit-PAB(159857-80-4)1HNMR

159857-80-4(MC-Val-Cit-PAB)Related Search:

FMoc-Val-Cit-PAB-PNP Val-cit-PAB-OH pyrene-2,7-diyldiboronic acid Fmoc-Val-Cit-OH FMoc-Val-Cit-PAB
L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-(hydroxyMethyl)phenyl]- ML-Val-Cit-PAB MC-Val-Cit-PAB, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- MC-Val-Cit-PAB MC-Val-it-PAB N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide EOS-60616 N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymeth N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureidopentan-2-yl]amino]-3-methyl-1-ox 6-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureido-2-pentyl]amino]-3-methyl-1-oxo-2-butyl]hexanamide N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide MC-Val-Cit-PAB-OH N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N2-[4-(hydroxymethyl)phenyl]-L-ornithinamide Benzenemethanol,2-chloro-8-nitro- MC-Val-Cit-PAB (ADC peptide linker) 6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-1-[[(1S)-1-[[4-(hydroxymethyl)phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]hexanamide MC-Val-Cit-PAB/MC-VC-PAB-OH N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N2-[4-(hydroxymethyl)phenyl]-L-ornithinamide 159857-80-4 59857-80-4 C28H40N6O7 ADCs ADC Linker ADC-Linker ADC-Linkers