AvibactaM
- CAS No.
- 1192500-31-4
- Chemical Name:
- AvibactaM
- Synonyms
- EOS-60408;AvibactaM;Avibactam acid;NXL-104 free acid;Avibactam free acid;Avibactam Impurity 37;(E)-7-fluoro-3-methylhept-4-en-2-one;AVIBACTAM FREE ACID (NXL-104 FREE ACID);(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-c...;(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carbox amide
- CBNumber:
- CB02582836
- Molecular Formula:
- C7H11N3O6S
- Molecular Weight:
- 265.24
- MDL Number:
- MFCD30478396
- MOL File:
- 1192500-31-4.mol
| Density | 1.85 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO |
| form | Powder |
| pka | -4.59±0.18(Predicted) |
| color | White to off-white |
| FDA UNII | 7352665165 |
AvibactaM price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0013803 | AVIBACTAM 95.00% | 1192500-31-4 | 5MG | $499.8 | 2021-12-16 | Buy |
| ApexBio Technology | A3205 | Avibactam | 1192500-31-4 | 5mg | $537 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013803 | AVIBACTAM 95.00% | 1192500-31-4 | 100MG | $995 | 2021-12-16 | Buy |
| Crysdot | CD31004353 | Avibactamfreeacid 98+% | 1192500-31-4 | 50mg | $1050 | 2021-12-16 | Buy |
| Chemenu | CM202052 | (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-ylhydrogensulfate 98% | 1192500-31-4 | 50mg | $982 | 2021-12-16 | Buy |
AvibactaM Chemical Properties,Uses,Production
Uses
Avibactam Butylammonium Salt is a novel β-lactamase inhibitor with a non-lactam structural scaffold. Avibactam irreversibly inhibits lactamase from Mycobacterium tuberculosis.
Definition
ChEBI: A member of the class of azabicycloalkanes that is (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group. Used (in the form of its sodium salt) n combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis.
Enzyme inhibitor
This non-β-lactam inhibitor of β-lactamase (FW = 261.27 g/mol; CAS 1192500-31-4), also known as NLX104 and AVE1330A, shows a spectrum of action against Classes A and C β-lactamase as well as selected Class D β-lactamase, enzymes that often confer resistance to β-lactam antibiotics. By forming a high-affinity complex with its target enzymes, avibactam enhances the antibacterial activity of certain β-lactam drugs, such as ceftaroline. With over 1000 known β-lactamase, the action of avibactam is apt to depend on the invidual active-site interactions. Mode of Action: Acylation and deacylation rates have been measured for the clinically important enzymes CTX-M-15, KPC-2, E. cloacae AmpC, P. aeruginosa AmpC, OXA-10, and OXA-48. The efficiency of acylation (kon/Ki) varies across the enzyme spectrum, from 1.1 x 101 M–1 s –1 for OXA-10 to 1.0 x 105 M–1 s –1 for CTX-M-15. Inhibition of OXA-10 was shown to follow a reversible covalent mechanism (see below), and the acylated OXA-10 displayed the longest residence time for deacylation, with a half-life of greater than 5 days. The inhibited enzyme forms are stable to hydrolysis for all enzymes with the exception of KPC-2, which displays slow hydrolytic route that involved fragmentation of the acyl-avibactam complex. In the case of TEM-1 lactamase, avibactam slowly covalently acylates its target, and the acylated enzyme subsequently undergoes slow deacylation (koff = 0.045 min?1 ) regenerating avibactam intact. Use as a Combined Drug: Combination of avibactim with extended-spectrum cephalosporins or aztreonam shows promise in inhibiting Klebsiella pneumoniae (KP) isolates harboring carbapenemases, or KPCs. Given abundant experience with ceftazidime and the significant improvement avibactam provides against contemporary β-lactamase-producing Gram-negative pathogens, this combination will likely play a role in the treatment of complicated urinary tract infections (as monotherapy) and complicated intra-abdominal infections (in combination with metronidazole) caused (or suspected to be caused) by otherwise resistant pathogens, such as extended spectrum β-lactamase-, AmpC-, or Klebsiella pneumoniae carbapenemase producing Enterobacteriaceae and multidrug-resistant P. aeruginosa.
AvibactaM Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 | sales@sdperfect.com | China | 294 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from AvibactaM manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Avibactam
1192500-31-4
|
US $0.00 / g | 1g | 98% HPLC | 1kg | shandong perfect biotechnology co.ltd | |
 |
2024-10-28 | Avibactam free acid
1192500-31-4
|
US $57.00-37.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2023-06-26 | Avibactam
1192500-31-4
|
US $200.00 / kg | 1kg | 99% | 1000kg/Months | Hebei Mingeng Biotechnology Co., Ltd |
-
- Avibactam
1192500-31-4
- US $0.00 / g
- 98% HPLC
- shandong perfect biotechnology co.ltd
-
- Avibactam free acid
1192500-31-4
- US $57.00-37.00 / mg
- TargetMol Chemicals Inc.
-
- Avibactam
1192500-31-4
- US $200.00 / kg
- 99%
- Hebei Mingeng Biotechnology Co., Ltd