GNE 7915
- CAS No.
- 1351761-44-8
- Chemical Name:
- GNE 7915
- Synonyms
- CS-1279;GNE 7915;GNE-7915, >=98%;GNE7915; GNE 7915;GNE 7915 USP/EP/BP;GNE-7915, 10 mM in DMSO;GNE7915, LRRK2 inhibitor;LRRK2,inhibit,GNE-7915,Inhibitor,Leucine-rich repeat kinase 2,GNE 7915;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone
- CBNumber:
- CB02667096
- Molecular Formula:
- C19H21F4N5O3
- Molecular Weight:
- 443.4
- MDL Number:
- MFCD25977005
- MOL File:
- 1351761-44-8.mol
| Melting point | 143 - 144°C |
|---|---|
| Boiling point | 629.9±65.0 °C(Predicted) |
| Density | 1.404±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | solid |
| pka | 2.80±0.10(Predicted) |
| color | Off-white to light yellow |
| CAS DataBase Reference | 1351761-44-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
GNE 7915 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16252 | GNE-7915 ≥98% | 1351761-44-8 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 16252 | GNE-7915 ≥98% | 1351761-44-8 | 10mg | $166 | 2024-03-01 | Buy |
| Cayman Chemical | 16252 | GNE-7915 ≥98% | 1351761-44-8 | 50mg | $547 | 2024-03-01 | Buy |
| Usbiological | 451389 | GNE 7915 | 1351761-44-8 | 10mg | $410 | 2021-12-16 | Buy |
| TRC | G766100 | GNE7915 | 1351761-44-8 | 10mg | $120 | 2021-12-16 | Buy |
GNE 7915 Chemical Properties,Uses,Production
Uses
GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2).
Uses
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]
GNE 7915 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32222 | 58 |
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | 16728589@qq.com | CHINA | 272 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22855 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
