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ChemicalBook >> CAS DataBase List >>GNE 7915

GNE 7915 suppliers

GNE 7915

CAS:
1351761-44-8
MF:
C19H21F4N5O3
MW:
443.4

Properties

Melting point:
143 - 144°C
Boiling point:
629.9±65.0 °C(Predicted)
Density 
1.404±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
solid
pka
2.80±0.10(Predicted)
color 
Off-white to light yellow

Safety Information

Symbol(GHS) 
GHS hazard pictograms
GHS07
Signal word 
Warning
Hazard statements 
H302-H315-H319-H335
Precautionary statements 
P261-P305+P351+P338

Use

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]

75 supplier list of "GNE 7915"

  • Product Name:GNE-7915
  • Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
  • Company Type: Reagent
  • Country/Region: CHINA
  • Product Name:[4-[[4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl](morpholino)methanone
  • Products Intro:Purity: >=98% | Package: 0.1g;0.25g;1g
  • Company Type: Reagent
  • Country/Region: UNITED STATES
  • Product Name:GNE-7915
  • Products Intro:Package: 100mg | CustNote: BOC Sciences also provides custom synthesis services for GNE-7915.
  • Company Type: Trader
  • Country/Region: UNITED STATES

$1.00/ 1g

  • Product Name: GNE 7915
  • Products Intro:Purity: 99% | Package: 1g;1USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:GNE-7915;GNE7915
  • Products Intro:Purity: 99.89% | Package: 1 mL * 10mM (in DMSO);10 mg;100 mg;200 mg;25 mg;5 mg;50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
  • Company Type: Trader
  • Country/Region: UNITED STATES
  • Product Name:GNE 7915
  • Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:GNE 7915
  • Products Intro:Purity: 99% | Package: 5KG;1KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:GNE-7915
  • Products Intro:Purity: 0 | Package: 1g; 5g; 25g; 1kg; 5kg; 25kg | CustNote: 0
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:GNE 7915
  • Products Intro:Purity: 0.95_) | Package: 10G;50G;100G | CustNote: Chemically Pure
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:GNE7915
  • Products Intro:Purity: 98% | Package: $48.9/5mg;$69.9/10mg;$140.9/25mg;$235.9/50mg;$400.9/100mg;Bulk package | CustNote: 98%
  • Company Type: Trader
  • Country/Region: UNITED STATES
You can find GNE 7915 suppliers, manufacturers, and distributors from countries such as CHINA, United States and the The Netherlands here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

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