ChemicalBook >> CAS DataBase List >>Cabotegravir (GSK744, GSK1265744)
Cabotegravir (GSK744, GSK1265744)
- CAS No.
- 1051375-10-0
- Chemical Name:
- Cabotegravir (GSK744, GSK1265744)
- Synonyms
- Cabotegravir;GSK1265744;GSK744;CS-2197;Caboteve;Cabot wei;SureCN82803;S/GSK1265744;Cabotegravin;SK744, GSK1265744
- CBNumber:
- CB02668664
- Molecular Formula:
- C19H17F2N3O5
- Molecular Weight:
- 405.35
- MDL Number:
- MFCD25976748
- MOL File:
- 1051375-10-0.mol
- MSDS File:
- SDS
Last updated:2024-11-20 11:41:24
| Boiling point | 664.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.57±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥19.35 mg/mL in DMSO with gentle warming |
| form | solid |
| pka | 4.50±1.00(Predicted) |
| color | White to yellow |
| FDA UNII | HMH0132Z1Q |
| ATC code | J05AJ04 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H400-H410 |
| Precautionary statements | P273-P391-P501-P273-P391-P501 |
Cabotegravir (GSK744, GSK1265744) price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27215 | GSK744 | 1051375-10-0 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 27215 | GSK744 | 1051375-10-0 | 10mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 27215 | GSK744 | 1051375-10-0 | 25mg | $131 | 2024-03-01 | Buy |
| Cayman Chemical | 27215 | GSK744 | 1051375-10-0 | 50mg | $243 | 2024-03-01 | Buy |
| TRC | C050100 | Cabotegravir | 1051375-10-0 | 100mg | $910 | 2021-12-16 | Buy |
Cabotegravir (GSK744, GSK1265744) Chemical Properties,Uses,Production
Uses
Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.
Definition
ChEBI: Cabotegravir is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (3S,11aR)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. It has a role as a HIV-1 integrase inhibitor. It is a difluorobenzene, a secondary carboxamide, a monocarboxylic acid amide and an organic heterotricyclic compound. It is a conjugate acid of a cabotegravir(1-).
Biological Activity
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, inhibiting HIV-1 integrase-catalyzed strand transfer with IC50 of 3 nM. Phase 2.
Mechanism of action
Caboggravir is a potent inhibitor of HIV integrase, which prevents the HIV virus from infecting human cells, while rilpivirine prevents the virus from replicating itself.
target
HIV integrase
Cabotegravir (GSK744, GSK1265744) Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 149)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15354 | 58 |
| Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 | evan@tyvovo.com | China | 148 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18777 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29883 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
Related articles
- How is GSK744 synthesised?
- GSK744 (Cabotegravir) is synthesised using Cabotegravir Pyridinone as a raw material through a series of chemical reactions.
- Dec 19，2023
View Lastest Price from Cabotegravir (GSK744, GSK1265744) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Cabotegravir
1051375-10-0
|
US $158.00-89.00 / mg | 99.92% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-11-16 | Cabotegravir (GSK744, GSK1265744)
1051375-10-0
|
US $240.00 / g | 10g | 99% Purity (What/sapp: +86 18145728414) | 1000 Tons/Month | Guangzhou Tengyue Chemical Co., Ltd. | |
 |
2021-07-02 | SureCN82803
1051375-10-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Cabotegravir
1051375-10-0
- US $158.00-89.00 / mg
- 99.92%
- TargetMol Chemicals Inc.
-
- Cabotegravir (GSK744, GSK1265744)
1051375-10-0
- US $240.00 / g
- 99% Purity (What/sapp: +86 18145728414)
- Guangzhou Tengyue Chemical Co., Ltd.
-
- SureCN82803
1051375-10-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
1051375-10-0(Cabotegravir (GSK744, GSK1265744))Related Search:
GSK744
(3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
Cabotegravir (GSK744, GSK1265744)
Cabotegravir Free Acid
Cyclic pyranopterin
SK744, GSK1265744
Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11aR)-
S/GSK1265744
(3S,11AR)-N-(2,4-DIFLUOROBENZYL)-6-HYDROXY-3-METHYL-5,7-DIOXO-2,3,5,7,11,11A-HEXAHYDROOXAZOLO[3,2-A]PYRIDO[1,2-D]PYRAZINE-8-CARBOXAMIDE
Cabotegravir(GSK1265744A,GSK-744)
Cabotegravir (GSK-1265744）
CS-2197
SureCN82803
GSK744 (S/GSK1265744)
Cabotegravir ,GSK744
Cabotegravir (GSK744, GSK1265744) USP/EP/BP
(3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexa...
Cabotegravir 13CD5
Cabot wei
GSK1265744
Cabotegravir
13C,2H2,15N]-Cabotegravir
Cabotegravir GSK744 GSK1265744 GSK-744
Cabotegravin
Caboteve
(3R,6S)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-6-methyl-8,11-dioxo-4-oxa-1,7-diazatricyclo[7.4.0.03,7]trideca-9,12-diene-12-carboxamide
1051375-10-0
C19H17F2N3O5
Inhibitors