Cabotegravir (GSK744, GSK1265744)
- CAS No.
- 1051375-10-0
- Chemical Name:
- Cabotegravir (GSK744, GSK1265744)
- Synonyms
- Cabotegravir;GSK1265744;GSK744;CS-2197;Cabotwe;Caboteve;Cabot wei;SureCN82803;S/GSK1265744;Cabotegravin
- CBNumber:
- CB02668664
- Molecular Formula:
- C19H17F2N3O5
- Molecular Weight:
- 405.35
- MDL Number:
- MFCD25976748
- MOL File:
- 1051375-10-0.mol
- MSDS File:
- SDS
Boiling point | 664.0±55.0 °C(Predicted) |
---|---|
Density | 1.57±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | insoluble in H2O; insoluble in EtOH; ≥19.35 mg/mL in DMSO with gentle warming |
form | solid |
pka | 4.50±1.00(Predicted) |
color | White to yellow |
FDA UNII | HMH0132Z1Q |
ATC code | J05AJ04 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS09 |
---|---|
Signal word | Warning |
Hazard statements | H400-H410 |
Precautionary statements | P273-P391-P501-P273-P391-P501 |
Cabotegravir (GSK744, GSK1265744) price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 27215 | GSK744 | 1051375-10-0 | 5mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 27215 | GSK744 | 1051375-10-0 | 10mg | $61 | 2024-03-01 | Buy |
Cayman Chemical | 27215 | GSK744 | 1051375-10-0 | 25mg | $131 | 2024-03-01 | Buy |
Cayman Chemical | 27215 | GSK744 | 1051375-10-0 | 50mg | $243 | 2024-03-01 | Buy |
TRC | C050100 | Cabotegravir | 1051375-10-0 | 100mg | $910 | 2021-12-16 | Buy |
Cabotegravir (GSK744, GSK1265744) Chemical Properties,Uses,Production
Uses
Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.
Definition
ChEBI: Cabotegravir is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (3S,11aR)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. It has a role as a HIV-1 integrase inhibitor. It is a difluorobenzene, a secondary carboxamide, a monocarboxylic acid amide and an organic heterotricyclic compound. It is a conjugate acid of a cabotegravir(1-).
Biological Activity
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, inhibiting HIV-1 integrase-catalyzed strand transfer with IC50 of 3 nM. Phase 2.
Mechanism of action
Caboggravir is a potent inhibitor of HIV integrase, which prevents the HIV virus from infecting human cells, while rilpivirine prevents the virus from replicating itself.
target
HIV integrase
Cabotegravir (GSK744, GSK1265744) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 | evan@tyvovo.com | China | 148 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18751 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
Related articles
- How is GSK744 synthesised?
- GSK744 (Cabotegravir) is synthesised using Cabotegravir Pyridinone as a raw material through a series of chemical reactions.
- Dec 19,2023
View Lastest Price from Cabotegravir (GSK744, GSK1265744) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-12-24 | Cabotegravir (GSK744, GSK1265744)
1051375-10-0
|
US $240.00 / g | 10g | 99% Purity (What/sapp: +86 18145728414) | 1000 Tons/Month | Guangzhou Tengyue Chemical Co., Ltd. | ||
2024-11-19 | Cabotegravir
1051375-10-0
|
US $158.00-89.00 / mg | 99.92% | 10g | TargetMol Chemicals Inc. | |||
2021-07-02 | SureCN82803
1051375-10-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- Cabotegravir (GSK744, GSK1265744)
1051375-10-0
- US $240.00 / g
- 99% Purity (What/sapp: +86 18145728414)
- Guangzhou Tengyue Chemical Co., Ltd.
- Cabotegravir
1051375-10-0
- US $158.00-89.00 / mg
- 99.92%
- TargetMol Chemicals Inc.
- SureCN82803
1051375-10-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd