Cabotegravir (GSK744, GSK1265744)
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- CAS-Nr.
- 1051375-10-0
- Englisch Name:
- Cabotegravir (GSK744, GSK1265744)
- Synonyma:
- Cabotegravir;GSK1265744;GSK744;CS-2197;Caboteve;Cabot wei;SureCN82803;S/GSK1265744;Cabotegravin;SK744, GSK1265744
- CBNumber:
- CB02668664
- Summenformel:
- C19H17F2N3O5
- Molgewicht:
- 405.35
- MOL-Datei:
- 1051375-10-0.mol
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Cabotegravir (GSK744, GSK1265744) Eigenschaften
- Siedepunkt:
- 664.0±55.0 °C(Predicted)
- Dichte
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- Löslichkeit
- insoluble in H2O; insoluble in EtOH; ≥19.35 mg/mL in DMSO with gentle warming
- Aggregatzustand
- solid
- pka
- 4.50±1.00(Predicted)
- Farbe
- White to yellow
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
Cabotegravir (GSK744, GSK1265744) Chemische Eigenschaften,Einsatz,Produktion Methoden
Biologische Aktivität
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, inhibiting HIV-1 integrase-catalyzed strand transfer with IC50 of 3 nM. Phase 2.
Mechanism of action
Caboggravir is a potent inhibitor of HIV integrase, which prevents the HIV virus from infecting human cells, while rilpivirine prevents the virus from replicating itself.
Cabotegravir (GSK744, GSK1265744) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cabotegravir (GSK744, GSK1265744) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 149)Lieferanten
- GSK744
- (3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
- Cabotegravir (GSK744, GSK1265744)
- Cabotegravir Free Acid
- Cyclic pyranopterin
- SK744, GSK1265744
- Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11aR)-
- S/GSK1265744
- (3S,11AR)-N-(2,4-DIFLUOROBENZYL)-6-HYDROXY-3-METHYL-5,7-DIOXO-2,3,5,7,11,11A-HEXAHYDROOXAZOLO[3,2-A]PYRIDO[1,2-D]PYRAZINE-8-CARBOXAMIDE
- Cabotegravir(GSK1265744A,GSK-744)
- Cabotegravir (GSK-1265744）
- CS-2197
- SureCN82803
- GSK744 (S/GSK1265744)
- Cabotegravir ,GSK744
- Cabotegravir (GSK744, GSK1265744) USP/EP/BP
- (3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexa...
- Cabotegravir 13CD5
- Cabot wei
- GSK1265744
- Cabotegravir
- 13C,2H2,15N]-Cabotegravir
- Cabotegravir GSK744 GSK1265744 GSK-744
- Cabotegravin
- Caboteve
- (3R,6S)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-6-methyl-8,11-dioxo-4-oxa-1,7-diazatricyclo[7.4.0.03,7]trideca-9,12-diene-12-carboxamide
- 1051375-10-0
- C19H17F2N3O5
- Inhibitors
