Chinese Japanese Germany Korea

Sacubitril Sodium

Sacubitril Sodium Structure
Sacubitril Sodium structure
CAS No.
149690-05-1
Chemical Name:
Sacubitril Sodium
Synonyms
Sacubitril sodium;Valsartan Sodium;Thacubatra sodium;AHU-377 sodium salt;Sacubitril Sodium Salt;AHU-377 (Sacubitril free base);Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate;sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate;(αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt
CBNumber:
CB03069990
Molecular Formula:
C24H28NNaO5
Molecular Weight:
433.47259
MDL Number:
MFCD32004488
MOL File:
149690-05-1.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24
Request For Quotation

Sacubitril Sodium Properties

Melting point 163-165°C
storage temp. -20°C, Hygroscopic
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Stability Hygroscopic
FDA UNII MOP72GEP8Z

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H413
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P

Sacubitril Sodium price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
DC Chemicals DC32235 Sacubitrilsodium 149690-05-1 250mg $700 2021-12-16 Buy
DC Chemicals DC32235 Sacubitrilsodium 149690-05-1 1g $1400 2021-12-16 Buy
Product number Packaging Price Buy
DC32235 250mg $700 Buy
DC32235 1g $1400 Buy

Sacubitril Sodium Chemical Properties,Uses,Production

Description

Sacubitril Sodium is a potent orally active NEP (enkephalinase) inhibitor with an IC50 of 5 nM. Sacubitril Sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril Sodium is a component of the heart failure drug LCZ696. Sacubitril Sodium is used in heart failure, hypertension and COVID-19 studies.

Uses

Sacubitril Sodium Salt is a salt of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

in vivo

In normotensive rats, pretreatment with Sacubitril sodium (3, 10 and 30 mg/kg, PO.) augments ANP-evoked plasma cGMP levels by 2.4, 3.3 and 4.0 fold, respectively (4h AUC compared to vehicle)[1].
Sacubitril sodium (30 and 100 mg/kg, PO) produces a dose-dependent antihypertensive effect in Dahl-SS rats[1].

Sacubitril Sodium synthesis

108-30-5
149690-12-0
149690-05-1
Synthesis of Sacubitril Sodium from Succinic anhydride and (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride

Sacubitril Sodium Preparation Products And Raw materials

Raw materials

AHU-377 (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride Succinic anhydride

Preparation Products

Sacubitril Sodium Suppliers

Global( 94)Suppliers
Supplier Tel Email Country ProdList Advantage
Lewoo Pharmatech(Shanghai)Co.,Ltd
+86-15800805830 +86-15800805830 miao@lewoopharma.com.cn China 184 58
Apeloa production Co.,Limited 		+8619933239880 admin@apcl.com.cn China 861 58
Watson Biotechnology Co.,Ltd 		+86-18186686046 +86-18186686046 sales01@watsonbiotech.cn China 5849 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15395 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Supplier Advantage
Lewoo Pharmatech(Shanghai)Co.,Ltd
58
Apeloa production Co.,Limited 		58
Watson Biotechnology Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
AFINE CHEMICALS LIMITED 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from Sacubitril Sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sacubitril Sodium pictures 2025-04-25 Sacubitril Sodium
149690-05-1
 US $0.00-0.00 / kg 1kg 99% 20MT Watson Biotechnology Co.,Ltd
Sacubitril Sodium pictures 2025-03-03 Sacubitril Sodium
149690-05-1
 US $0.00 / kg 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
Sacubitril sodium pictures 2025-02-13 Sacubitril sodium
149690-05-1
 US $1.00 / g 1g 98% 1000 Apeloa production Co.,Limited

149690-05-1(Sacubitril Sodium )Related Search:

LCZ696(valsartan + sacubitril) impurity 35 [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-methyl ester, calcium salt (2:1), (αR,γS)- LCZ696(valsartan + sacubitril) impurity 31 [1,1'-Biphenyl]-4-pentanoic acid, γ-(acetylamino)-α-methyl-, (αR,γS)- LCZ696(valsartan + sacubitril) impurity 34
2S,4R-Sacubitril Sacubatrava valsartan sodium hydrate Sacubitril Impurity 43 Sacubitril Methyl esterQ: What is Sacubitril Methyl ester Q: What is the CAS Number of Sacubitril Methyl ester Sacubitrilat-d5

1of2

Sacubitril Sodium Salt Valsartan Sodium sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate AHU-377 (Sacubitril free base) Sacubitril sodium AHU-377 sodium salt Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate Thacubatra sodium (αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt 149690-05-1