DESMOSTEROL
- CAS No.
- 313-04-2
- Chemical Name:
- DESMOSTEROL
- Synonyms
- Desmostero;esmosterol;DESMOSTEROL;24-DEHYDROCHOLESTEROL;Cholesterol impurity B;desmosterol crystalline;Cholesta-5,24-dien-3-ol;5,24-Cholestadien-3β-ol;Cholesterol Impurity 12;5, 24-CHOLESTADIEN-3β-OL
- CBNumber:
- CB0307682
- Molecular Formula:
- C27H44O
- Molecular Weight:
- 384.65
- MDL Number:
- MFCD00056432
- MOL File:
- 313-04-2.mol
- MSDS File:
- SDS
| Melting point | 121.5°, also reported as 119-119.5° |
|---|---|
| alpha | D27 -41.0° (c = 1 in chloroform) |
| Boiling point | 483.2±14.0 °C(Predicted) |
| Density | 1.00±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 15.03±0.70(Predicted) |
| color | Wihte to Off-White |
| FDA UNII | ANP93865R8 |
DESMOSTEROL price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D6513 | Desmosterol ≥84% (GC) | 313-04-2 | 5mg | $86 | 2024-03-01 | Buy |
| Sigma-Aldrich | D6513 | Desmosterol ≥84% (GC) | 313-04-2 | 10mg | $149 | 2024-03-01 | Buy |
| Cayman Chemical | 14943 | 24-dehydro Cholesterol ≥98% | 313-04-2 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 14943 | 24-dehydro Cholesterol ≥98% | 313-04-2 | 5mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 14943 | 24-dehydro Cholesterol ≥98% | 313-04-2 | 10mg | $120 | 2024-03-01 | Buy |
DESMOSTEROL Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Desmosterol has been used as a sterol to test its interaction with human protein Mincle and as an internal standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). It may be used as in the preparation of lipid monolayers.
Uses
24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies. During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols. However, defects in cholesterol synthesis can lead to a condition called, desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol. 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.[Cayman Chemical]
Uses
A metabolite of Cholesterol (C432501).
Definition
ChEBI: A cholestanoid that is cholesta-5,24-diene substituted by a beta-hydroxy group at position 3. It is an intermediate metabolite obtained during the synthesis of cholesterol.
General Description
Desmosterol lacks a double bond between C24 and C25 compared to cholesterol. It is present in the membrane of spermatozoa and astrocytes and is the major brain sterol.
Biochem/physiol Actions
Desmosterol is a precursor of cholesterol in the Bloch pathway and the enzyme 24-dehydrocholesterol reductase catalyzes this step. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. Desmosterol is a liver X receptor (LXR) agonist . It is a potential therapeutic target for treating the neurodegenerative disorder. Desmosterol regulates inflammatory signaling in macrophages.
DESMOSTEROL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32079 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8670 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9237 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11922 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Guangzhou PI PI Biotech Inc | 020-81716320 +86-13602409664 | Sales@pipitech.com | China | 3633 | 55 |
View Lastest Price from DESMOSTEROL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-20 | Desmosterol
313-04-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Desmosterol
313-04-2
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.