ChemicalBook >> CAS DataBase List >>Leniolisib
Leniolisib
- CAS No.
- 1354690-24-6
- Chemical Name:
- Leniolisib
- Synonyms
- CS-2818;CDZ 173;Leniolisib;leniolisib(CDZ 173);CDZ173;CDZ-173;CDZ 173;Rupatadine Impurity 2-d8;inhibit,Inhibitor,Phosphoinositide 3-kinase,Leniolisib,PI3K,CDZ-173,CDZ 173;(S)-1-(3-((6-(6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one;1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]-
- CBNumber:
- CB03311734
- Molecular Formula:
- C21H25F3N6O2
- Molecular Weight:
- 450.46
- MDL Number:
- MOL File:
- 1354690-24-6.mol
Last updated:2024-07-02 08:54:58
storage temp. | Store at -20°C |
---|---|
solubility |
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.11(Max Conc. mM) DMSO:71.67(Max Conc. mg/mL);159.09(Max Conc. mM) Ethanol:16.5(Max Conc. mg/mL);36.63(Max Conc. mM) |
form | A crystalline solid |
color | White to off-white |
FDA UNII | L22772Z9CP |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
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Leniolisib price More Price(17)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 28078 | Leniolisib | 1354690-24-6 | 1mg | $49 | 2024-03-01 | Buy |
Cayman Chemical | 28078 | Leniolisib | 1354690-24-6 | 25mg | $770 | 2024-03-01 | Buy |
Cayman Chemical | 28078 | Leniolisib | 1354690-24-6 | 5mg | $227 | 2024-03-01 | Buy |
Cayman Chemical | 28078 | Leniolisib | 1354690-24-6 | 10mg | $403 | 2024-03-01 | Buy |
ChemScene | CS-7524 | Leniolisib 99.25% | 1354690-24-6 | 10mg | $350 | 2021-12-16 | Buy |
Leniolisib Chemical Properties,Uses,Production
Biological Activity
Leniolisib (CDZ 173) is a potent and selective PI3Kδ inhibitor with IC50s of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively.
target
Target | Value |
PI3Kδ (Cell-free assay) | 0.011 μM |
PI3Kα (Cell-free assay) | 0.244 μM |
0.424 μM | |
DNA-PK () | 0.88 μM |
DNA-PK (Cell-free assay) | 0.88 μM |
![1354691-73-8](/CAS/20210111/GIF/1354691-73-8.gif)
![79-03-8](/CAS/GIF/79-03-8.gif)
![1354690-24-6](/CAS/20200515/GIF/1354690-24-6.gif)
Synthesis of Leniolisib from 1-Pyrrolidinecarboxylic acid, 3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-, 1,1-dimethylethyl ester, (3S)- and Propionyl chloride
Leniolisib Preparation Products And Raw materials
Raw materials
1-Pyrrolidinecarboxylic acid, 3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-, 1,1-dimethylethyl ester, (3S)-
1-Pyrrolidinecarboxylic acid, 3-[[5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido[4,3-d]pyrimidin-4-yl]amino]-, 1,1-dimethylethyl ester, (3S)-
1-Pyrrolidinecarboxylic acid, 3-[(5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino]-, 1,1-dimethylethyl ester, (3S)-
6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
5-bromo-2-methoxy-3-(trifluoromethyl)pyridine
1of2
Preparation Products
Leniolisib Suppliers
Global( 69)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1460 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Leniolisib
CDZ173;CDZ-173;CDZ 173
CS-2818
leniolisib(CDZ 173)
CDZ 173
1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]-
(S)-1-(3-((6-(6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one
inhibit,Inhibitor,Phosphoinositide 3-kinase,Leniolisib,PI3K,CDZ-173,CDZ 173
Rupatadine Impurity 2-d8
1354690-24-6
C21H25F3N6O2