ChemicalBook >> CAS DataBase List >>Leniolisib

Leniolisib

Leniolisib structure

CAS No.: 1354690-24-6

Chemical Name:: Leniolisib

Synonyms: CS-2818;CDZ 173;Leniolisib;leniolisib(CDZ 173);CDZ173;CDZ-173;CDZ 173;Rupatadine Impurity 2-d8;inhibit,Inhibitor,Phosphoinositide 3-kinase,Leniolisib,PI3K,CDZ-173,CDZ 173;(S)-1-(3-((6-(6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one;1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]-

CBNumber:: CB03311734

Molecular Formula:: C21H25F3N6O2

Molecular Weight:: 450.46

MDL Number:

MOL File:: 1354690-24-6.mol

Last updated:2024-07-02 08:54:58

Request For Quotation

Leniolisib Properties

storage temp.	Store at -20°C
solubility	DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.11(Max Conc. mM) DMSO:71.67(Max Conc. mg/mL);159.09(Max Conc. mM) Ethanol:16.5(Max Conc. mg/mL);36.63(Max Conc. mM)
form	A crystalline solid
color	White to off-white
FDA UNII	L22772Z9CP

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

Leniolisib price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	28078	Leniolisib	1354690-24-6	1mg	$49	2024-03-01	Buy
Cayman Chemical	28078	Leniolisib	1354690-24-6	25mg	$770	2024-03-01	Buy
Cayman Chemical	28078	Leniolisib	1354690-24-6	5mg	$227	2024-03-01	Buy
Cayman Chemical	28078	Leniolisib	1354690-24-6	10mg	$403	2024-03-01	Buy
ChemScene	CS-7524	Leniolisib 99.25%	1354690-24-6	10mg	$350	2021-12-16	Buy

Product number	Packaging	Price	Buy
28078	1mg	$49	Buy
28078	25mg	$770	Buy
28078	5mg	$227	Buy
28078	10mg	$403	Buy
CS-7524	10mg	$350	Buy

Leniolisib Chemical Properties,Uses,Production

Biological Activity

Leniolisib (CDZ 173) is a potent and selective PI3Kδ inhibitor with IC50s of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> PI3Kβ
(Cell-free assay)

Target	Value
PI3Kδ (Cell-free assay)	0.011 μM
PI3Kα (Cell-free assay)	0.244 μM
0.424 μM
DNA-PK ()	0.88 μM
DNA-PK (Cell-free assay)	0.88 μM

Leniolisib synthesis

Synthesis of Leniolisib from 1-Pyrrolidinecarboxylic acid, 3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-, 1,1-dimethylethyl ester, (3S)- and Propionyl chloride

Leniolisib Preparation Products And Raw materials

Raw materials

1-Pyrrolidinecarboxylic acid, 3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-, 1,1-dimethylethyl ester, (3S)- 1-Pyrrolidinecarboxylic acid, 3-[[5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido[4,3-d]pyrimidin-4-yl]amino]-, 1,1-dimethylethyl ester, (3S)- 1-Pyrrolidinecarboxylic acid, 3-[(5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino]-, 1,1-dimethylethyl ester, (3S)- 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine

2-Methoxy-3-(trifluoromethyl)pyridine (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine 2-Chloro-3-(trifluoromethyl)pyridine Propionyl chloride

1of2

Preparation Products

Leniolisib Suppliers

Global( 69)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30250	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1460	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Chemtour Biotech Co., Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58

Leniolisib CDZ173;CDZ-173;CDZ 173 CS-2818 leniolisib(CDZ 173) CDZ 173 1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]- (S)-1-(3-((6-(6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one inhibit,Inhibitor,Phosphoinositide 3-kinase,Leniolisib,PI3K,CDZ-173,CDZ 173 Rupatadine Impurity 2-d8 1354690-24-6 C21H25F3N6O2