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Leniolisib

Leniolisib structure

CAS No.: 1354690-24-6

Chemical Name:: Leniolisib

Synonyms: CS-2818;CDZ 173;Leniolisib;leniolisib(CDZ 173);CDZ173;CDZ-173;CDZ 173;Rupatadine Impurity 2-d8;inhibit,Inhibitor,Phosphoinositide 3-kinase,Leniolisib,PI3K,CDZ-173,CDZ 173;(S)-1-(3-((6-(6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one;1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]-

CBNumber:: CB03311734

Molecular Formula:: C21H25F3N6O2

Molecular Weight:: 450.46

MDL Number:

MOL File:: 1354690-24-6.mol

Last updated:2024-11-04 20:04:50

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Leniolisib Properties

storage temp.	Store at -20°C
solubility	DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.11(Max Conc. mM) DMSO:71.67(Max Conc. mg/mL);159.09(Max Conc. mM) Ethanol:16.5(Max Conc. mg/mL);36.63(Max Conc. mM)
form	A crystalline solid
color	White to off-white
FDA UNII	L22772Z9CP

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

Leniolisib price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	28078	Leniolisib	1354690-24-6	1mg	$49	2024-03-01	Buy
Cayman Chemical	28078	Leniolisib	1354690-24-6	25mg	$770	2024-03-01	Buy
Cayman Chemical	28078	Leniolisib	1354690-24-6	5mg	$227	2024-03-01	Buy
Cayman Chemical	28078	Leniolisib	1354690-24-6	10mg	$403	2024-03-01	Buy
ChemScene	CS-7524	Leniolisib 99.25%	1354690-24-6	10mg	$350	2021-12-16	Buy

Product number	Packaging	Price	Buy
28078	1mg	$49	Buy
28078	25mg	$770	Buy
28078	5mg	$227	Buy
28078	10mg	$403	Buy
CS-7524	10mg	$350	Buy

Leniolisib Chemical Properties,Uses,Production

Biological Activity

Leniolisib (CDZ 173) is a potent and selective PI3Kδ inhibitor with IC50s of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> PI3Kβ
(Cell-free assay)

Target	Value
PI3Kδ (Cell-free assay)	0.011 μM
PI3Kα (Cell-free assay)	0.244 μM
0.424 μM
DNA-PK ()	0.88 μM
DNA-PK (Cell-free assay)	0.88 μM

Leniolisib synthesis

Synthesis of Leniolisib from 1-Pyrrolidinecarboxylic acid, 3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-, 1,1-dimethylethyl ester, (3S)- and Propionyl chloride

Leniolisib Preparation Products And Raw materials

Raw materials

1-Pyrrolidinecarboxylic acid, 3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-, 1,1-dimethylethyl ester, (3S)- 1-Pyrrolidinecarboxylic acid, 3-[[5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido[4,3-d]pyrimidin-4-yl]amino]-, 1,1-dimethylethyl ester, (3S)- 1-Pyrrolidinecarboxylic acid, 3-[(5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino]-, 1,1-dimethylethyl ester, (3S)- 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine

2-Methoxy-3-(trifluoromethyl)pyridine (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine 2-Chloro-3-(trifluoromethyl)pyridine Propionyl chloride

1of2

Preparation Products

Leniolisib Suppliers

Global( 71)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32820	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32063	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30241	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38463	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1460	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Chemtour Biotech Co., Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

View Lastest Price from Leniolisib manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-04	Leniolisib 1354690-24-6	US $72.00-235.00 / mg		99.88%	10g	TargetMol Chemicals Inc.

Leniolisib
1354690-24-6
US $72.00-235.00 / mg
99.88%
TargetMol Chemicals Inc.

Leniolisib CDZ173;CDZ-173;CDZ 173 CS-2818 leniolisib(CDZ 173) CDZ 173 1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]- (S)-1-(3-((6-(6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one inhibit,Inhibitor,Phosphoinositide 3-kinase,Leniolisib,PI3K,CDZ-173,CDZ 173 Rupatadine Impurity 2-d8 1354690-24-6 C21H25F3N6O2