1,3,5-Trimethoxybenzene
- CAS No.
- 621-23-8
- Chemical Name:
- 1,3,5-Trimethoxybenzene
- Synonyms
- Benzene, 1,3,5-trimethoxy-;1,3,5-Trimethyoxybenzene;PHLOROGLUCINOL TRIMETHYL ETHER;1,3,5-Methoxybenzene;2,4,6-Trimethoxybenzene;1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%;Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole;1,3,5-TriMetho;TRISMETHOXYBENZENE;5-TriMethoxybenzene
- CBNumber:
- CB0371005
- Molecular Formula:
- C9H12O3
- Molecular Weight:
- 168.19
- MDL Number:
- MFCD00008385
- MOL File:
- 621-23-8.mol
- MSDS File:
- SDS
| Melting point | 50-53 °C (lit.) |
|---|---|
| Boiling point | 255 °C (lit.) |
| Density | 1,126g/cm |
| refractive index | 1,533 |
| Flash point | 186 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| color | White to cream |
| Water Solubility | insoluble |
| BRN | 1307993 |
| InChIKey | LKUDPHPHKOZXCD-UHFFFAOYSA-N |
| LogP | 1.605 (est) |
| CAS DataBase Reference | 621-23-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 00VJI3VG3D |
| NIST Chemistry Reference | 1,3,5-Trimethoxybenzene(621-23-8) |
| EPA Substance Registry System | 1,3,5-Trimethoxybenzene (621-23-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn,F | |||||||||
| Risk Statements | 22-20/21/22 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| RIDADR | 1325 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DC2810000 | |||||||||
| Hazard Note | Flammable Solid/Harmful | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29093090 | |||||||||
| NFPA 704 |
|
1,3,5-Trimethoxybenzene price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 138827 | 1,3,5-Trimethoxybenzene ReagentPlus , ≥99% | 621-23-8 | 10g | $36 | 2024-03-01 | Buy |
| Sigma-Aldrich | 138827 | 1,3,5-Trimethoxybenzene ReagentPlus , ≥99% | 621-23-8 | 50g | $110 | 2024-03-01 | Buy |
| TCI Chemical | P0250 | 1,3,5-Trimethoxybenzene >98.0%(GC) | 621-23-8 | 25g | $37 | 2024-03-01 | Buy |
| TCI Chemical | P0250 | 1,3,5-Trimethoxybenzene >98.0%(GC) | 621-23-8 | 100g | $111 | 2024-03-01 | Buy |
| Alfa Aesar | A13981 | 1,3,5-Trimethoxybenzene, 99% | 621-23-8 | 10g | $32.4 | 2024-03-01 | Buy |
1,3,5-Trimethoxybenzene Chemical Properties,Uses,Production
Chemical Properties
white to cream crystalline powder. Insoluble in water.
Uses
1,3,5-Trimethoxybenzene is a major scent component of the Chinese rose odour. 1,3,5-Trimethoxybenzene is also a useful synthetic intermediate and is used to synthesize triaryl- and triheteroarylmethanes.
Definition
ChEBI: 1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite.
General Description
1,3,5-Trimethoxybenzene effectively cleaves p-methoxybenzyl protecting group on various alcohols and acids. It is the major scent compound present in Chinese rose species.
Synthesis
A solution of anhydrous phloroglucinol (6.3 g，0.05 mole) in dryacetone (100 ml) is refluxed for 6 hr under anhydrous conditions withdimethyl sulphate (15. 6 ml，20.8 g, 0.165 mole) in presence of ignitedpotassium carbonate (40 g).The mixture is filtered, and the inorganic saltswashed with hot acetone (2 × 20 ml). The combined acetone solution isdistilled and the residue macerated with crushed ice. It is extracted withether, the ether extracts washed with sodium hydroxide solution (5%),water，dried (sodium sulphate) and distilled. Yield 1,3,5-Trimethoxybenzene 6 g (71.4 %).M.p 52-3° (lit. m.p.52-53°).
Solubility in organics
Soluble in Methanol, Ether, Ethanol, Benzene.
Solubility in water
Insoluble
Purification Methods
Sublime it under vacuum. [Beilstein 6 III 635, 6 IV 7362.]
1,3,5-Trimethoxybenzene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang Kinso Technology Co., LTD. | +8619857958369 | sales@kinsopharma.com | China | 54 | 58 |
| Chengdu Yuanda Chemical Co., Ltd | 28-85356300 +8618980937689 | sales@ydachem.com | CHINA | 94 | 58 |
| Zhejiang Karry Pharmachem Co., Ltd. | +8613567161161 | info@karrypharma.com | China | 34 | 58 |
| Beijing Wisdom Chemicals Co., Ltd. | +8613701363759 | market@wisdomchem.com | China | 254 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8804 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12829 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531153977 | allison@yan-xi.com | China | 5855 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5887 | 58 |
| Hebei Dangtong Import and export Co LTD | +86-86-4001020630 +8619831957301 | admin@hbdangtong.com | China | 1000 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18147 | 58 |
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- Sep 6，2024
View Lastest Price from 1,3,5-Trimethoxybenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-02-14 | 1,3,5-Trimethoxybenzene
621-23-8
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-02-14 | 1,3,5-Trimethoxybenzene
621-23-8
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2024-12-12 | 1,3,5-Trimethoxybenzene
621-23-8
|
US $89.00-80.00 / kg | 1kg | 99% | 5000kg | Hebei Dangtong Import and export Co LTD |
-
- 1,3,5-Trimethoxybenzene
621-23-8
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 1,3,5-Trimethoxybenzene
621-23-8
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 1,3,5-Trimethoxybenzene
621-23-8
- US $89.00-80.00 / kg
- 99%
- Hebei Dangtong Import and export Co LTD