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ChemicalBook >> CAS DataBase List >>N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide

N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide

N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide Structure
N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide structure
CAS No.
1119503-63-7
Chemical Name:
N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide
Synonyms
JNc-440;JNc-440 (JNc440);N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide;N-(3-(2,2-Diphenylacetamido)propyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide;2-Quinazolinecarboxamide, N-[3-[(2,2-diphenylacetyl)amino]propyl]-3,4-dihydro-4-oxo-
CBNumber:
CB04020167
Molecular Formula:
C26H24N4O3
Molecular Weight:
440.49
MDL Number:
MOL File:
1119503-63-7.mol
Last updated:2024-07-02 08:54:58
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N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide Properties

Density 1.26±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka 10.06±0.20(Predicted)
color White to off-white

N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide Chemical Properties,Uses,Production

Biological Activity

JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice[1]. JNc-440 (1 mg/kg; IV; single dosage) improves endothelium-dependent relaxation in small resistance arteries and to lower blood pressure[1].

References

[1]. He D, et al. Treatment of hypertension by increasing impaired endothelial TRPV4-KCa2.3 interaction. EMBO Mol Med. 2017 Nov;9(11):1491-1503.

N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62163 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4738 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19696 58
Supplier Advantage
Aladdin Scientific 		58
Bide Pharmatech Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide JNc-440 (JNc440) JNc-440 2-Quinazolinecarboxamide, N-[3-[(2,2-diphenylacetyl)amino]propyl]-3,4-dihydro-4-oxo- N-(3-(2,2-Diphenylacetamido)propyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide 1119503-63-7