Taxifolin
- CAS No.
- 480-18-2
- Chemical Name:
- Taxifolin
- Synonyms
- DIHYDROQUERCETIN;distylin;taxifoliol;Larch extract;(+)-TAXIFOLIN;(2R,3R)-(+)-Taxifolin;(2R,3R)-DIHYDROQUERCETIN;Taxifolin (Dihydroquercetin);CPD-474;Lavitol
- CBNumber:
- CB0402424
- Molecular Formula:
- C15H12O7
- Molecular Weight:
- 304.25
- MDL Number:
- MFCD00006845
- MOL File:
- 480-18-2.mol
Melting point | 230-233°C (dec.) |
---|---|
Boiling point | 365.09°C (rough estimate) |
Density | 1.3326 (rough estimate) |
refractive index | 1.4790 (estimate) |
storage temp. | -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 7.39±0.60(Predicted) |
color | White to Yellow |
BRN | 5299277 |
InChI | InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1 |
InChIKey | CXQWRCVTCMQVQX-LSDHHAIUSA-N |
SMILES | [C@H]1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O |
LogP | 0.950 |
CAS DataBase Reference | 480-18-2(CAS DataBase Reference) |
FDA UNII | 9SOB9E3987 |
EPA Substance Registry System | 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- (480-18-2) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
Risk Statements | 22 | |||||||||
Safety Statements | 22-24/25 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | LK6920000 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29329990 | |||||||||
NFPA 704 |
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Taxifolin price More Price(52)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 78666 | Taxifolin analytical standard | 480-18-2 | 25mg | $75.7 | 2024-03-01 | Buy |
Sigma-Aldrich | 78666 | Taxifolin analytical standard | 480-18-2 | 100mg | $254 | 2024-03-01 | Buy |
Sigma-Aldrich | 03890585 | Taxifolin primary reference standard | 480-18-2 | 10mg | $330 | 2023-06-20 | Buy |
TCI Chemical | T3666 | (+)-Taxifolin | 480-18-2 | 200MG | $114 | 2024-03-01 | Buy |
TCI Chemical | T3666 | (+)-Taxifolin | 480-18-2 | 1G | $344 | 2024-03-01 | Buy |
Taxifolin Chemical Properties,Uses,Production
Structural chemistry
Taxifolin is a subclass of flavanonols, an isoflavanone in flavonoids family. The basic structure of two phenyl groups (ring A and ring B) which are joined together by a heterocyclic ring referred to as ring C . The structure contains 3-hydroxyl group at the C ring which is connected to the B ring at carbon-2. Taxifolin is a pentahydroxyflavone containing five hydroxyl groups at the 3-, 3'-, 4'-, 5- and 7-positions. It has two stereocenters on the C-ring and 4 stereoisomers. It with the configuration of (2R, 3R) is one of them and it comprises 2 pairs of enantiomers.
Description
Taxifolin, a chemical substance extracted from pine plants such as larch and Douglas fir. It belongs to the bioflavonoid pseudo-vitamin P, and its scientific name is dihydroquercetin. Japanese scholar Fukui first isolated it from the leaves of conifers (Chamaecyparis obtusa), and its biological activity was subsequently discovered and confirmed.
Chemical Properties
Yellow Solid
Uses
An antioxidant flavenoid.
Uses
(+)-Taxifolin is a flavanon compound which modulates chemopreventive genes.
Uses
Reference Standard in the analysis of herbal medicinal products
Application
Taxifolin is a flavonoid commonly found in onion, milk, French maritime pine bark and Douglas fir bark. It is also used in various commercial preparations like Legalon?, Pycnogenol?, and Venoruton?. This review focuses on taxifolin’s biological activities and related molecular mechanisms. It showed promising pharmacological activities in the management of inflammation, tumors, microbial infections, oxidative stress, cardiovascular, and liver disorders. The anti-cancer activity was more prominent than other activities evaluated using different in vitro and in vivo models. Further research on the pharmacokinetics, in-depth molecular mechanisms, and safety profile using well-designed randomized clinical studies are suggested to develop a drug for human use.
Definition
ChEBI: A taxifolin that has (2R,3R)-configuration.
General Description
Taxifolin is a plant flavonoid, which may find applications in the treatment of coronary heart disease, angina pectoris, cerebral thrombosis, cerebral infarction and sequelae.
Taxifolin Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 289 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5870 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 2989 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 1143 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 873 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Shanghai finete Pharmaceutical Co., Ltd. | +86-18221039705 | CHINA | 139 | 55 | |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29892 | 58 |
Related articles
- Synthesis and application of Taxifolin
- Taxifolin, a very important dihydroflavonol compound with the formula of C15H12O7, is an ordorless, colorless acicular crystal....
- Jul 8,2022
- Pharmacological activities of Taxifolin
- Taxifolin, a chemical substance extracted from pine plants such as larch and Douglas fir. It belongs to the bioflavonoid pseud....
- Dec 22,2021
View Lastest Price from Taxifolin manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-27 | Taxifolin
480-18-2
|
US $0.00-0.00 / Kg/Drum | 1KG | 98%min HPLC | 10 KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-08-27 | Taxifolin
480-18-2
|
US $0.00-0.00 / kg | 1kg | 1-98% | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. | |
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2024-08-26 | Taxifolin
480-18-2
|
US $0.00-0.00 / kg | 1kg | 99% | 500 | Wuhan Haorong Biotechnology Co.,Ltd |