ChemicalBook >> CAS DataBase List >>1-Methyl-4-pyrazole boronic acid pinacol ester
1-Methyl-4-pyrazole boronic acid pinacol ester
- CAS No.
- 761446-44-0
- Chemical Name:
- 1-Methyl-4-pyrazole boronic acid pinacol ester
- Synonyms
- 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1H-Pyrazole, 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-Methyl-4-(4;Angelica oil 8015-64-3;e-4-boronic acid pinacoL;1-Methylpyrazole-4-boroni...;1-Methyl-4-(4,4,5,5-Tetramethy
- CBNumber:
- CB0414153
- Molecular Formula:
- C10H17BN2O2
- Molecular Weight:
- 208.07
- MDL Number:
- MFCD03789259
- MOL File:
- 761446-44-0.mol
Last updated:2025-01-27 09:38:02
| Melting point | 59-64 °C(lit.) |
|---|---|
| Boiling point | 308.3±15.0 °C(Predicted) |
| Density | 1.05±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (slightly), Methanol (Slightly) |
| pka | 2.09±0.10(Predicted) |
| form | Crystals |
| color | Off-white to yellow |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3 |
| InChIKey | UCNGGGYMLHAMJG-UHFFFAOYSA-N |
| SMILES | N1(C)C=C(B2OC(C)(C)C(C)(C)O2)C=N1 |
| CAS DataBase Reference | 761446-44-0(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xn,F,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Flammable | |||||||||
| TSCA | No | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
1-Methyl-4-pyrazole boronic acid pinacol ester price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 595314 | 1-Methylpyrazole-4-boronic acid pinacol ester 95% | 761446-44-0 | 1g | $33.88 | 2024-03-01 | Buy |
| Sigma-Aldrich | 595314 | 1-Methylpyrazole-4-boronic acid pinacol ester 95% | 761446-44-0 | 5g | $114.6 | 2024-03-01 | Buy |
| TCI Chemical | M2339 | 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole >98.0%(GC) | 761446-44-0 | 1g | $52 | 2024-03-01 | Buy |
| TCI Chemical | M2339 | 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole >98.0%(GC) | 761446-44-0 | 5g | $66 | 2024-03-01 | Buy |
| Alfa Aesar | H53139 | 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester, 97% | 761446-44-0 | 1g | $108.65 | 2024-03-01 | Buy |
1-Methyl-4-pyrazole boronic acid pinacol ester Chemical Properties,Uses,Production
Chemical Properties
White to light yellow crystal powde
Uses
suzuki reaction
Uses
1-Methyl-4-pyrazole boronic acid pinacol ester is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.
Synthesis
To the solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.40 g, 2.06 mmol) in THF (10 mL) was added NaH (0.1.00 g, 4.12 mmol) followed by methyl iodide (0.25 mL, 4.12 mmol) at 0° C and the reaction mixture was stirred at ambient temperature for 4 hr. The reaction was quenched with saturated NH4Cl solution (20 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with brine (20 mL), dried over sodium sulfate, and distilled under reduced pressure to obtain 1-Methyl-4-pyrazole boronic acid pinacol ester.
Synthesis of 1-Methyl-4-pyrazole boronic acid pinacol ester from 4-Pyrazoleboronic acid pinacol ester and Iodomethane
1-Methyl-4-pyrazole boronic acid pinacol ester Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
Global( 434)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 | wangxuhui1985@126.com | China | 57 | 55 |
| Lianhe Aigen Pharmatech Co.,Ltd. | +undefined+undefined18918657159 | sales@lianhe-aigen.com | China | 316 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19825 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20234 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 988 | 58 |
View Lastest Price from 1-Methyl-4-pyrazole boronic acid pinacol ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | 1-Methylpyrazole-4-boronic acid pinacol ester
761446-44-0
|
US $50.00 / kg | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2025-04-04 | 1-Methyl-4-pyrazole boronic acid pinacol ester
761446-44-0
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2025-03-21 | 1-Methylpyrazole-4-boronic acid pinacol ester
761446-44-0
|
US $100.00 / kg | 1kg | 99 | 200tons | Hebei Mujin Biotechnology Co.,Ltd |
-
- 1-Methylpyrazole-4-boronic acid pinacol ester
761446-44-0
- US $50.00 / kg
- 99
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 1-Methyl-4-pyrazole boronic acid pinacol ester
761446-44-0
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1-Methylpyrazole-4-boronic acid pinacol ester
761446-44-0
- US $100.00 / kg
- 99
- Hebei Mujin Biotechnology Co.,Ltd
761446-44-0(1-Methyl-4-pyrazole boronic acid pinacol ester)Related Search:
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1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(1-Methyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1-Methylpyrazole-4-boronic acid pinacol ester 95%
1-Methylpyrazole-4-boronic acid pinacol ester
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1-Methyl-1H-pyrazole-4-boronic acid pinacol
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1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan
3-hydroxy-2,3-diMethylbutan-2-yl hydrogen 1-Methyl-1H-pyrazol-4-ylboronate
1-METHYL-4-1H-PYRAZOLEBORONIC ACID, PINACOL ESTER
1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-1H-PYRAZOLE
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole1-Methylpyrazole-4-boronic acid pinacol ester
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole ,95%
1-Methylpyrazole-4-boronic acid pinacol ester ,98%
1-Methylpyrazole-4-boroni...
1-Methyl-4-(4
1-Methy-4-(4,4,5,5,-tertamethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1-Methylpyrazole-4-boronic acid pinacol ester (Related Reference)
1-MethylPyrazole-4-Boronic acid Pinacolate
2-(1-Methyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1-Methyl-1H-pyrazole-4-boronic acid, pinacol ester 99%
1-methyl-4-(4-tetramethyl-1-dioxaborolan-2-yl)-1H-
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole>
e-4-boronic acid pinacoL
(1-METHYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
1H-Pyrazole, 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER
1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER
1- methylpyrazole -4- boracic acid methyl alcohol ester
Angelica oil 8015-64-3
N-Methylpyrazole-4-boronicacidpinacolester
Tranexamic Acid Impurity 27-13C2
761446-44-0
761446-18-6
76146-44-0
C10H17BN2O2
C10H19BN2O3
Boronate Esters
Boronic Acids and Derivatives
Chemical Synthesis
Heteroaryl Boronate Esters
Organometallic Reagents
Heterocyclic Building Blocks
Organoborons
Pyrazole
Boronic acid