JTE-607 dihydrochloride
- CAS No.
- 188791-09-5
- Chemical Name:
- JTE-607 dihydrochloride
- Synonyms
- JTE-607 HCl;JTE-607 dihydrochloride;N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride;(S)-Ethyl 2-(3,5-dichloro-2-hydroxy-4-(2-(4-methylpiperazin-1-yl)ethoxy)benzamido)-3-phenylpropanoate dihydrochloride;IL-6,IL-1β,endotoxin,CPSF3,Anti-inflammatory,TNF-α,JTE-607,JTE 607,Interleukin Related,IL-8,Cytokine,Inhibitor,Inflammatory,JTE607,Immunosuppression,IL-10,inhibit
- CBNumber:
- CB04718628
- Molecular Formula:
- C25H32Cl3N3O5
- Molecular Weight:
- 560.9
- MDL Number:
- MOL File:
- 188791-09-5.mol
- MSDS File:
- SDS
storage temp. | -20° (des.) |
---|---|
solubility | Soluble in DMSO (up to 25 mg/ml). |
form | solid |
color | Off-white to pale yellow |
Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
FDA UNII | 2B68H6BWCX |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
JTE-607 dihydrochloride price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 5185 | JTE607dihydrochloride ≥98%(HPLC) | 188791-09-5 | 10 | $265 | 2021-12-16 | Buy |
Tocris | 5185 | JTE607dihydrochloride ≥98%(HPLC) | 188791-09-5 | 50 | $1113 | 2021-12-16 | Buy |
TRC | J211965 | JTE607Dihydrochloride | 188791-09-5 | 10mg | $235 | 2021-12-16 | Buy |
TRC | J211965 | JTE607Dihydrochloride | 188791-09-5 | 50mg | $950 | 2021-12-16 | Buy |
JTE-607 dihydrochloride Chemical Properties,Uses,Production
Description
JTE-607 (188791-09-5) inhibits inflammatory cytokine production in human peripheral blood mononuclear cells (PBMC’s) without causing immunosuppression: IC50’s = 11 nM (TNF-α), 5.9 nM (IL-1β), 8.8 nM (IL-6), 7.3 nM (IL-8), and 9.1 nM (IL-10).1?It displayed efficacy in a mouse model of septic shock.2?JTE-607 also showed inhibitory activity against acute myelogenous leukemia cell lines.3,4?Recently, the mechanism of action of JTE-607 (a pro-drug, with the active species being the free acid) has been found to be inhibition of pre-messenger RNA endonuclease Cleavage and Polyadenylation Specificity Factor 3 (CPSF3).5,6?This prevents release of newly synthesized mRNA’s resulting in read-through transcription and the formation of DNA-RNA hybrid R-loop structures. Transcripts down-regulated by JTE-607 were related to DNA damage-based phenotype.
Uses
JTE 607 Dihydrochloride is a cytokine release inhibitor.
Definition
ChEBI: JTE-607 dihydrochloride is the dihydrochloride salt of JTE-607. It is a cytokine inhibitor which suppresses the production of proinflammatory cytokines such as interleukin (IL-1beta), IL-6, IL-8, granulocyte macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor (TNF-alpha). It acts as a pro-drug which is cleaved by carboxylesterase 1 (CES1) to its active free acid form, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3). It has a role as an anti-inflammatory agent, an antineoplastic agent, an apoptosis inducer, a prodrug, a cardioprotective agent and a CPSF3 inhibitor. It contains a JTE-607(2+).
storage
Desiccate at RT
References
References/Citations 1) Kakutani?et al.?(1999),?JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice; Inflamm. Res.,?48?461 2) Iwamura?et al.?(2004),?Comparative study of glucocorticoids, cyclosporine A, and JTE-607 [(-)-Ethyl-N{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate dihydrochloride] in a mouse septic shock model; J. Pharmacol. Exp. Ther.,?311?1256 3) Uesato?et al.?(2006),?JTE-607, a multiple cytokine production inhibitor, ameliorates disease in a SCID mouse xenograft acute myeloid leukemia model; Exp. Hematol.,?34?1385 4) Tajima?et al.?(2010),?JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells; Cancer Sci.,?101?774 5) Kakegawa?et al.?(2019), JTE-607, a multiple cytokine production inhibitor, targets CPSF3 and inhibits pre-mRNA; Biochem. Biophys. Res. Commun.,?518?32 6) Ross?et al.?(2020),?CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma; Nat. Chem. Biol.,?16?50
JTE-607 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
JTE-607 dihydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4296 | 55 | |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8014 | 62 |