ChemicalBook >> CAS DataBase List >>CH7057288
CH7057288
- CAS No.
- 2095616-82-1
- Chemical Name:
- CH7057288
- Synonyms
- CH7057288;Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288;4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
- CBNumber:
- CB04797034
- Molecular Formula:
- C32H31N3O5S
- Molecular Weight:
- 569.67
- MDL Number:
- MOL File:
- 2095616-82-1.mol
Last updated:2024-07-02 08:54:58
CH7057288 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 5mg | $350 | 2021-12-16 | Buy |
ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 10mg | $550 | 2021-12-16 | Buy |
ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 25mg | $1100 | 2021-12-16 | Buy |
ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 50mg | $1750 | 2021-12-16 | Buy |
ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 100mg | $2750 | 2021-12-16 | Buy |
CH7057288 Chemical Properties,Uses,Production
Biological Activity
CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.
in vitro
In cell-free kinase assays, CH7057288 has selective inhibitory activity against TRKA, TRKB and TRKC, and inhibits the proliferation of cells containing TRK fusions. It inhibits MAPK and E2F signaling pathways.
target
Target | Value |
TrkA (Cell-free assay) | 1.1 nM |
TrkC (Cell-free assay) | 5.1 nM |
7.8 nM |
CH7057288 Preparation Products And Raw materials
Raw materials
Preparation Products
CH7057288 Suppliers
Global( 37)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5224 | 58 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18021 | 56 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7887 | 56 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4287 | 55 |
CH7057288
4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288
2095616-82-1