ChemicalBook >> CAS DataBase List >>CH7057288
CH7057288
- CAS No.
- 2095616-82-1
- Chemical Name:
- CH7057288
- Synonyms
- CH7057288;Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288;4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
- CBNumber:
- CB04797034
- Molecular Formula:
- C32H31N3O5S
- Molecular Weight:
- 569.67
- MDL Number:
- MOL File:
- 2095616-82-1.mol
Last updated:2024-07-02 08:54:58
CH7057288 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 10mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 25mg | $1100 | 2021-12-16 | Buy |
| ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 50mg | $1750 | 2021-12-16 | Buy |
| ChemScene | CS-0028214 | CH7057288 98.52% | 2095616-82-1 | 100mg | $2750 | 2021-12-16 | Buy |
CH7057288 Chemical Properties,Uses,Production
Biological Activity
CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.
in vitro
In cell-free kinase assays, CH7057288 has selective inhibitory activity against TRKA, TRKB and TRKC, and inhibits the proliferation of cells containing TRK fusions. It inhibits MAPK and E2F signaling pathways.
target
| Target | Value |
| TrkA (Cell-free assay) | 1.1 nM |
| TrkC (Cell-free assay) | 5.1 nM |
| 7.8 nM |
CH7057288 Preparation Products And Raw materials
Raw materials
Preparation Products
CH7057288 Suppliers
Global( 37)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4692 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3449 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18018 | 56 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4197 | 55 |
CH7057288
4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288
2095616-82-1