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D-Fructose 1,6-bisphosphate trisodium salt

CAS No.
38099-82-0
Chemical Name:
D-Fructose 1,6-bisphosphate trisodium salt
Synonyms
FDP,3Na;FDP-Na3H;D-Fructose-1;FDP trisodium;Einecs 253-778-0;HARDEN-YOUNG ESTER;HEXOSE DIPHOSPHATE;Esafosfan trisodium;hexose diphosphoric acid;Diphosphofructose trisodium
CBNumber:
CB0493640
Molecular Formula:
C6H15NaO12P2
Molecular Weight:
364.11
MDL Number:
MFCD00135872
MOL File:
38099-82-0.mol
Last updated:2024-12-18 13:37:16

D-Fructose 1,6-bisphosphate trisodium salt Properties

Melting point 127°C
storage temp. −20°C
form Powder
color White to off-white
Water Solubility Soluble in water at 50mg/ml
FDA UNII T1E52G2C9I
EPA Substance Registry System D-Fructose, 1,6-bis(dihydrogen phosphate), trisodium salt (38099-82-0)

SAFETY

Risk and Safety Statements

WGK Germany  3
10-21

D-Fructose 1,6-bisphosphate trisodium salt price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F6803 D-Fructose 1,6-bisphosphate trisodium salt hydrate ≥98% (TLC) 38099-82-0 1g $92.9 2024-03-01 Buy
Sigma-Aldrich F6803 D-Fructose 1,6-bisphosphate trisodium salt hydrate ≥98% (TLC) 38099-82-0 5g $322 2024-03-01 Buy
Alfa Aesar J66349 D-Fructose-1,6-bisphosphate trisodium salt 38099-82-0 1g $19.65 2024-03-01 Buy
Alfa Aesar J66349 D-Fructose-1,6-bisphosphate trisodium salt 38099-82-0 25g $99.65 2024-03-01 Buy
Sigma-Aldrich F6803 D-Fructose 1,6-bisphosphate trisodium salt hydrate ≥98% (TLC) 38099-82-0 10mg $31.4 2024-03-01 Buy
Product number Packaging Price Buy
F6803 1g $92.9 Buy
F6803 5g $322 Buy
J66349 1g $19.65 Buy
J66349 25g $99.65 Buy
F6803 10mg $31.4 Buy

D-Fructose 1,6-bisphosphate trisodium salt Chemical Properties,Uses,Production

Biochem/physiol Actions

Fructose-1,6-biphosphate (F1,6P) is a glycolytic intermediate produced by the transfer of a phosphate from ATP to fructose-6-phosphate by the enzyme phosphofructokinase. Fructose-1,6-biphosphate, along with fructose-2,6-biphosphate, modulates the activity of phosphofructokinase-1 (PFK-1), the rate-limiting step in glycolysis. During glycolysis, aldolase splits Fructose-1,6-biphosphate into dihydroxacetone phosphate (DHAP) and glyceraldehyde phosphate. Fructose-1,6-biphosphate is also an allosteric activator of the M2 isoform of Pyruvate Kinase (PK-M2), the predominant form of pyruvate kinase in cancer cells.

Uses

D-Fructose-1,6-bisphosphate trisodium salt is used to reduce ischemia-reperfusion injury in rats.

Application

D-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It may be used as an allosteric activator of enzymes such as pyruvate kinase and NAD+-dependent L-(+)-lactate dehydrogenase, as an inhibitor of acetate kinase and as a substrate to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1,6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury.

Purification Methods

Fructose-1,6-diphosphate is best purified via the acid strychnine salt which is stable for several months. To remove the strychnine, dissolve 5g in H2O (150mL), and add 5N NaOH (or KOH to obtain the K salt) to pH 8.3 (phenolphthalein) with vigorous stirring. Remove the precipitate by centrifugation, wash with cold H2O (2x 25mL), extract with CHCl3 until the extract is free of strychnine (ca 8 to 10times, Mandelein spot test). Freeze-dry the aqueous solution to give the Na salt which is hygroscopic. It has been recrystallised from aqueous EtOH as the octahydrate, m 125o, [] D +2.6o (c 1, H2O). A neutral solution of the salt keeps well in a frozen state for over several months. [Neuberg et al. Arch Biochem 3 33 1943, Sable Biochemical Preparations 2 52 1952, Stumpf J Biol Chem 182 261 1950]. The calcium salt can be partially purified by dissolving in ice-cold N HCl (1g per 10mL) and re-precipitating by dropwise addition of 2N NaOH: the precipitate and supernatant are heated on a boiling water bath for a short time, then filtered, and the precipitate is washed with hot water. The magnesium salt can be precipitated from a cold aqueous solution by adding four volumes of EtOH. The tetramethyl ester is an oil with n D 1.4648, [] 18 +20.2 (c 0.4, MeOH). [Schulbach & Rauchenberger Chem Ber 60 1178 1927, Beilstein 1 IV 4424.]

D-Fructose 1,6-bisphosphate trisodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 193)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12834 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021 lisa@kingfinertech.com China 3010 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569266 15319487004 1015@dideu.com China 3942 58
Neostar United (Changzhou) Industrial Co., Ltd.
+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8838 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58

View Lastest Price from D-Fructose 1,6-bisphosphate trisodium salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
D-Fructose 1,6-bisphosphate trisodium salt pictures 2024-12-13 D-Fructose 1,6-bisphosphate trisodium salt
38099-82-0
US $0.00 / G 1G 98%min 30kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Fructose Diphosphate Sodium pictures 2024-11-19 Fructose Diphosphate Sodium
38099-82-0
US $0.00-0.00 / kg 1kg 98% 1000kg Hebei ZB Gamay Biological Technology Co.,Ltd
Esafosfan trisodium pictures 2024-11-19 Esafosfan trisodium
38099-82-0
US $33.00 / mg 99.87% 10g TargetMol Chemicals Inc.

D-Fructose 1,6-bisphosphate trisodium salt Spectrum

FDP-Na3H D(+)FRUCTOFURANOSE 1,6-DIPHOSPHATE TRISODIUM SALT D-FruCLose 1,6-bisphosphate trisodiuM salt D-Fructose 1,6-bisphosphate hydrate trisodium salt Harden-Young ester, Hexose diphosphate hydrate trisodium salt, D(+)Fructofuranose 1,6-diphosphate hydrate trisodium salt D-Fructose-1,6-biphosphate trisodium salt octahydrate HEXOSE DIPHOSPHATE TRISODIUM SALT HEXOSE DIPHOSPHATE HARDEN-YOUNG ESTER D-Fructose 1,6-bisphosphate trisodium salt octahydrate D-FRUCTOSE-1 6-DIPHOSPHORIC ACID TRISOD& hexose diphosphoric acid D-Fructose, 1,6-bis(dihydrogen phosphate), sodium salt (1:3) Einecs 253-778-0 Fructose-1,6-bis(dihydrophosphate), trisodium salt Hexose diphosphate trisodium salt hydrate 6-diphosphate trisodiuM salt octahydrate D-Fructose-1 D-Fructose 1,6-bisphosphate trisodium salt anhydrous D-FRUCTOSE 1,6-DIPHOSPHATE TRISODIUM SALT d-fructose,1,6-bis(dihydrogenphosphate),trisodiumsalt D-Fructose-1,6-Phosphate trisodiuM salt D(+)Fructofuranose 1,6-diphosphate trisodium salt hydrate D-Fructose 1,6-bisphosphate sodium salt D-FRUCTOSE 1,6-BISPHOSPHATE TRISODIUM SALT acetic acid (12-acetyloxy-6,11-dioxo-1,2,3,4-tetrahydrotetracen-5-yl) ester FDP,3Na FDP trisodium Esafosfan trisodium Diphosphofructose trisodium D-Fructose1,6-bisphosphatetrisodiumsal D-Fructose 1,6-bisphosphate trisodium salt hydrate, ≥98% Fructose bisphosphate sodium/Fosfructose trisodium Fosfructose trisodium (Diphosphofructose (trisodium)) Fosfructose trisodium|||D-Fructose-1,6-diphosphate trisodium salt octahydrate|||FDP trisodium|||Diphosphofructose trisodium 38099-82-0 C6H11Na3O12P2 C6H10O4OPO3H22 Carbohydrates BioChemical Biochemicals and Reagents Monosaccharide Dextrins、Sugar & Carbohydrates