Entecavir

Entecavir Properties

Melting point	249-252°C
Boiling point	661.4±65.0 °C(Predicted)
Density	1.81±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Sparingly)
form	powder
pka	14.22±0.60(Predicted)
color	white to beige
optical activity	[α]/D +25 to +40°, c = 0.2 in H2O
Stability	Hygroscopic
CAS DataBase Reference	142217-69-4(CAS DataBase Reference)
FDA UNII	NNU2O4609D
NCI Drug Dictionary	Baraclude
ATC code	J05AF10

Pharmacokinetic data

Protein binding	13%
Excreted unchanged in urine	75%
Volume of distribution	Large
Biological half-life	128-149 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H320-H335
Precautionary statements	P264-P270-P301+P312-P330
Safety Statements	24/25
WGK Germany	3
HS Code	29339900

Entecavir price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1103	Entecavir ≥98% (HPLC)	142217-69-4	10MG	$61	2023-06-20	Buy
Sigma-Aldrich	SML1103	Entecavir ≥98% (HPLC)	142217-69-4	50MG	$247	2023-06-20	Buy
Tocris	6234	Entecavir ≥98%(HPLC)	142217-69-4	10	$50	2021-12-16	Buy
Tocris	6234	Entecavir ≥98%(HPLC)	142217-69-4	50	$198	2021-12-16	Buy
TRC	E558900	Entecavir	142217-69-4	250mg	$130	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML1103	10MG	$61	Buy
SML1103	50MG	$247	Buy
6234	10	$50	Buy
6234	50	$198	Buy
E558900	250mg	$130	Buy

Entecavir Chemical Properties,Uses,Production

Pharmacodynamics

Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV). It is designed to selectively inhibit the Hepatitis B virus, blocking all three steps in the replication process. Entecavir is more efficient than an older Hepatitis B drug, lamivudine.

Description

Entecavir is a cyclopentyl guanosine analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection, and it is the third nucleoside or nucleotide analog to be marketed for this indication. Lamivudine, a deoxythiacytosine analog, and adefovir dipivoxil, a nucleotide analog, have been marketed since 1998 and 2002, respectively. Entecavir and adefovir are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections.

Chemical Properties

White to Off-White/Yellow Crystalline Powder

Originator

BMS (US)

Uses

Entecavir is a new generation of guanine nucleoside analogues oral medicine for treatment of hepatitis B virus infection in, mainly for the treatment of adult patients with viral replication activity and serum transaminase continued to increase, or liver tissue for pathological activity of chronic hepatitis B, is currently down virus the fastest and the most powerful, the mutation rate lowest nucleoside analogues.

Definition

ChEBI: Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it ha no activity against HIV. It is used for the treatment of chronic hepatitis B.

Trade name

Baraclude (BMS)

Mechanism of action

Entecavir is a nucleoside analog, or more specifically, a deoxyguanosine analogue that belongs to a class of carbocyclic nucleosides and inhibits reverse transcription, DNA replication and transcription in the viral replication process.

Pharmacokinetics

Entecavir had a mean terminal half-life ranging from 128 to 149 hours and an effective half-life of approximately 24 hours. Elimination was predominantly through renal excretion, with mean urinary recovery ranging from 62% to 73%.

Clinical Use

Treatment of chronic hepatitis B virus infection in patients >16 years of age.
Entecavir comes as a tablet and solution (liquid) to take by mouth. It is usually taken once a day on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal. Take entecavir at around the same time every day.

Side effects

The most common side effects of entecavir: the increase of ALT, fatigue, dizziness, nausea, abdominal pain, abdominal discomfort, abdominal discomfort, liver, muscle, insomnia, rubella and indigestion, also be found in neutrophils decreased slightly.
These adverse reactions were mild to moderate. It also found that, as the same type of antiviral drugs, entecavir and the first generation of antiviral drugs have similar side effects, such as acid poisoning, hepatomegaly, liver fatty degeneration in the withdrawal will appear rebound phenomenon.

Synthesis

Entecavir is synthesized from 4-trimethylsilyl-3-butyn-2-one and acrolein. The key features of its preparation are: (1) a stereoselective boron–aldol reaction to afford the acyclic carbon skeleton of the methylenecylopentane moiety; (2) its cyclization by a Cp2TiCl-catalyzed intramolecular radical addition of an epoxide to an alkyne; and (3) the coupling with a purine derivative by a Mitsunobu reaction.

storage

Store at -20°C

Entecavir synthesis

Synthesis of Entecavir from Cyclopentanemethanol, 5-(acetyloxy)-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylene-, 1-acetate, (1R,3S,5S)-

Entecavir Preparation Products And Raw materials

Raw materials

6H-Purin-6-one, 9-[(1S,3R,4S)-4-(acetyloxy)-2-methylene-3-[[(4-nitrobenzoyl)oxy]methyl]cyclopentyl]-2-amino-1,9-dihydro- Cyclopentanemethanol, 5-(acetyloxy)-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylene-, 1-acetate, (1R,3S,5S)-

Preparation Products

Entecavir Suppliers

Global( 518)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9314	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	988	58
Wuhan Golt Biotech Co., Ltd.	+8615389281203	maria@goltbiotech.com	China	970	58
Shenzhen Monkono Technology Co.,Ltd	+86-17063441314	sansbiotech@outlook.com	China	677	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8812	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	997	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	025-84209270 15906146951		CHINA	115	55
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9214	55

Supplier	Advantage
Baoji Guokang Bio-Technology Co., Ltd.	58
Sinoway Industrial co., ltd.	58
Wuhan Golt Biotech Co., Ltd.	58
Shenzhen Monkono Technology Co.,Ltd	58
Hebei Weibang Biotechnology Co., Ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	55
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Hangzhou FandaChem Co.,Ltd.	55

View Lastest Price from Entecavir manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-22	Entecavir 142217-69-4	US $0.00-0.00 / g	1g	99% HPLC	1000kg	HangZhou RunYan Pharma Technology Co.,LTD.
2024-11-22	Entecavir 142217-69-4	US $0.00 / g	1g	99%min	1000g	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-22	Entecavir 142217-69-4	US $0.00 / Kg/Bag	2Kg/Bag	96% up	20 tons	Sinoway Industrial co., ltd.

Entecavir
142217-69-4
US $0.00-0.00 / g
99% HPLC
HangZhou RunYan Pharma Technology Co.,LTD.

Entecavir
142217-69-4
US $0.00 / g
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

Entecavir
142217-69-4
US $0.00 / Kg/Bag
96% up
Sinoway Industrial co., ltd.

142217-69-4(Entecavir)Related Search:

methylol cellulose CHLOROPHOSPHONAZO III CARBOXYMETHYLCELLULOSE SODIUM SALT Trimethylolpropane Tris(hydroxymethyl)aminomethane

Tris(hydroxymethyl)nitromethane 1,1,1-Tris(hydroxymethyl)ethane 6-Aminocaproic acid Glycine 2-Hydroxyethyl methacrylate

Guanine entecavir hydrate,ENTECAVIR MONOHYDRATE ALTRENOGEST Entacapone Sodium hydroxymethylglycinate

2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Docetaxel Imatinib mesylate

1of4

Aids098045 Aids-098045 Enticavir EntikaweiPian 2-Amino-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-3H-purin-6(9H)-one ,99.7% (1S,3R,4S)-9-[4-Hydroxy-3-(hydroxyMethyl)-2-Methylenecyclopentyl]guanine Entecavir Anhydrous 20MG/100MG/100G Entecavir Tablets Entecavir (as hydrate) Entecavir,99%e.e. Entecavi ENTECAVIR, 98-102% entecavir Baraclude 2-Amino-9-[4-hydroxy-3-(hydroxymethyl)-2-methylidene-cyclopentyl]-3H-purin-6-one,Baraclude ENTECAVIR 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one 2-Amino-9-[4-hydroxy-3-(hydroxymethyl)-2-methylidene-cyclopentyl]-3H-purin-6-one SQ 34676 6-H-Purin-6-one-,2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl] Entecavir USP Impurity B 2-amino-9-[(1R,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-3H-purin-6-one hydrate CS-863 CS-1236 Entecavir, BMS200475 Entecavir（SQ 34676 Entecavir/Entecavir Monohydrate Entecavir USP/EP/BP 2-Amino-9-(4-hydroxy-3-hydroxymethyl-2-methylene-cyclopentyl)-3,9-dihydro-purin-6-one Etv 2-amino-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one Baraclude entikawei 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylene-cyclopentyl]-1H-purin-6-one 142217-69-4 209216-23-6 12477-69-4 The latest anti hepatitis b anti-aids drugs Anti-virals Heterocycles API Nucleotides and Nucleosides Bases & Related Reagents Intermediates & Fine Chemicals Nucleotides Pharmaceuticals Inhibitors Antiviral Agents 142217-69-4