Entecavir
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Entecavir 속성
- 녹는점
- 249-252°C
- 끓는 점
- 661.4±65.0 °C(Predicted)
- 밀도
- 1.81±0.1 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 14.22±0.60(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- optical activity
- [α]/D +25 to +40°, c = 0.2 in H2O
- 안정성
- 흡습성
- CAS 데이터베이스
- 142217-69-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
안전지침서 | 24/25 | ||
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WGK 독일 | 3 | ||
HS 번호 | 29339900 | ||
유해 물질 데이터 | 142217-69-4(Hazardous Substances Data) |
그림문자(GHS): |
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신호 어: | Warning | |||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Entecavir C화학적 특성, 용도, 생산
개요
Entecavir is a cyclopentyl guanosine analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection, and it is the third nucleoside or nucleotide analog to be marketed for this indication. Lamivudine, a deoxythiacytosine analog, and adefovir dipivoxil, a nucleotide analog, have been marketed since 1998 and 2002, respectively. Entecavir and adefovir are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections.화학적 성질
White to Off-White/Yellow Crystalline Powder정의
ChEBI: Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it ha no activity against HIV. It is used for the treatment of chronic hepatitis B.상품명
Baraclude (BMS)Clinical Use
Treatment of chronic hepatitis B virus infection in patients >16 years of age.Entecavir comes as a tablet and solution (liquid) to take by mouth. It is usually taken once a day on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal. Take entecavir at around the same time every day.
Entecavir 준비 용품 및 원자재
원자재
6H-Purin-6-one, 9-[(1S,3R,4S)-4-(acetyloxy)-2-methylene-3-[[(4-nitrobenzoyl)oxy]methyl]cyclopentyl]-2-amino-1,9-dihydro-
Cyclopentanemethanol, 5-(acetyloxy)-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylene-, 1-acetate, (1R,3S,5S)-
준비 용품
Entecavir 공급 업체
글로벌( 507)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9321 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 990 | 58 |
Wuhan Golt Biotech Co., Ltd. | +8615389281203 |
maria@goltbiotech.com | China | 980 | 58 |
Shenzhen Monkono Technology Co.,Ltd | +86-17063441314 |
sansbiotech@outlook.com | China | 677 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 |
CHINA | 115 | 55 | |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9332 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
Entecavir 관련 검색:
트리메틸올에탄 6-아미노 카프로산 글리신 2-하이드록시에틸 메트아크릴산 구아닌 나트륨 카르복시메틸 셀룰로스 트리메틸롤프로판 트리스(하이드록시메틸)아미노메탄 트리스(하이드록시메틸)니트로메탄 나트륨 하이드록시메틸아미노아세테이트 라미부딘
entecavir hydrate,ENTECAVIR MONOHYDRATE
methylol cellulose
CHLOROPHOSPHONAZO III
ALTRENOGEST
Entacapone
Docetaxel
2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one