눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313
피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313
눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
NFPA 704
0
3
0
Entacapone C화학적 특성, 용도, 생산
개요
Entacapone was introduced in Finland, Germany and Sweden as an
adjunctive treatment with L-dopa in Parkinson’s disease. Entacapone is the
second drug in its class to reach the market; it can be obtained by
basecatalyzed condensation of the corresponding benzaldehyde with a
cyanoacetamide. Entacapone is a highly selective and orally-active catechol-0-
methyltransferase (COMT) inhibitor ; by inhibiting metabolism of L-dopa when
given as an adjuvant in patients with Parkinson’s disease, Entacapone markedly
prolongs the effects of L-dopa and improves its bioavailability. Results from
clinical studies showed that 200mglday Entacapone coadministered with L-dopa
lowered the dose of the latter required to reduce fluctuations in motor
performance.
화학적 성질
Yellow Crystalline Solid
용도
(E)-Isomer of Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian
정의
ChEBI: A monocarboxylic acid amide that is N,N-diethylprop-2-enamide in which the hydrogen at position 2 is substituted by a cyano group and the hydrogen at the 3E position is substituted by a 3,4-dihydroxy-5
nitrophenyl group.
일반 설명
Entacapone, (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide (Comtan),is a nitrocatechol that is practically insoluble in water (pKa＝4.50). Entacapone is rapidly absorbed after oral administrationand does not cross the BBB. Entacapone does not distributewidely into tissues because of its high plasma proteinbinding and it is completely metabolized before excretion.The main metabolic pathway is by isomerization to the cisisomerfollowed by direct glucuronidation of the parent andthe cis-isomer. The glucuronide conjugates are inactive.Entacapone is eliminated in the feces (90%) and urine (10%).Entacapone is indicated as an adjunct to levodopa/carbidopato treat patients with idiopathic PD who experience the signsand symptoms of end-of-dose wearing off.
