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SENKTIDE

SENKTIDE structure

CAS No.: 106128-89-6

Chemical Name:: SENKTIDE

Synonyms: SENKTIDE;succinyl(asp6;Senktide?, BR;SENKTIDE (6-11);SUC-DF(ME)FGLM-NH2;SUC-DF-(NMEF)-GLM-NH2;M.W. 842.1 C40H55N7O11S;Senktide trifluoroacetate salt;Suc-Asp6, Me-Phe8] Substance P;Suc-[Asp6,MePhe8]substance P(6-11)

CBNumber:: CB0679033

Molecular Formula:: C40H55N7O11S

Molecular Weight:: 841.97

MDL Number:: MFCD00076799

MOL File:: 106128-89-6.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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SENKTIDE Properties

Boiling point	1262.6±65.0 °C(Predicted)
Density	1.290±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	DMSO : 50 mg/mL (59.38 mM; Need ultrasonic)
pka	4.23±0.10(Predicted)
form	film
color	colorless
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	3

SENKTIDE price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0764	Senktide trifluoroacetate salt ≥95% (HPLC)	106128-89-6	500μg	$134	2024-03-01	Buy
Cayman Chemical	16721	Senktide ≥98%	106128-89-6	500μg	$81	2024-03-01	Buy
Cayman Chemical	16721	Senktide ≥98%	106128-89-6	1mg	$143	2024-03-01	Buy
Cayman Chemical	16721	Senktide ≥98%	106128-89-6	5mg	$593	2024-03-01	Buy
Tocris	1068	Senktide	106128-89-6	500U	$129	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML0764	500μg	$134	Buy
16721	500μg	$81	Buy
16721	1mg	$143	Buy
16721	5mg	$593	Buy
1068	500U	$129	Buy

SENKTIDE Chemical Properties,Uses,Production

Uses

Senktide is an NK3 agonist.

Uses

Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50 = 0.5-3 nM). It less potently agonizes the NK1 receptor (EC50 = 35 μM) and is without effect on the NK2 receptor. Senktide is used to study the action of the NK3 receptor in cells and in animals.

Biological Activity

Senktide is a selective Neurokinin NK3 tachykinin receptor agonist. Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system th at are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract.', 'Senktide treatment in follicular phase goats enhances the liberation of luteinizing hormone (LH) and advance the time of ovulation. Senktide has the ability to suppress gonadotropin-releasing hormone (GnRH) transcription. Treatment with senktide stimulates c-Fos and improve activator protein-1 (AP-1) activity.

in vivo

I.c.v. injection of Senktide causes a dose-dependent increase in total distance traveled (F_6,72=6.344, P<0.001). This increase reaches statistical significance compare to the vehicle-treated group at 0.06 nmol and higher. The Senktide-induced increase in locomotor activity brought about by 0.1 nmol of Senktide is significantly and dose-dependently decreased by the tachykinin NK₃ receptor antagonists talnetant at 30 mg/kg and SB222200 at 30 mg/kg, but not by osanetant, when tested in parallel in a single experiment (F_7,78=10.32, P<0.001), although a non-significant reduction is observed. However, when tested using another vehicle (Vitamin E and glycofurol), osanetant does decrease activity significantly compare to Senktide-treated gerbils (F_2,30=10.10, P<0.001)^[1].

storage

Store at -20°C

SENKTIDE Preparation Products And Raw materials

Raw materials

Preparation Products

SENKTIDE Suppliers

Global( 103)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19777	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29808	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3512	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
Chengdu Youngshe Chemical Co., Ltd.	58
TargetMol Chemicals Inc.	58
Hebei Miaoyin Technology Co.,Ltd	58

View Lastest Price from SENKTIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	SENKTIDE 106128-89-6	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-11-19	Senktide 106128-89-6	US $132.00-57.00 / mg		100%	10g	TargetMol Chemicals Inc.
2020-02-12	SENKTIDE 106128-89-6	US $7.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

SENKTIDE
106128-89-6
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

Senktide
106128-89-6
US $132.00-57.00 / mg
100%
TargetMol Chemicals Inc.

SENKTIDE
106128-89-6
US $7.00 / KG
99%
Career Henan Chemical Co

106128-89-6(SENKTIDE)Related Search:

SUBSTANCE P (6-11) SENKTIDE, [PHE-3,4,5-3H]-,SENKTIDE, [PHENYLALANYL-3,4,5-3H]- 3-(4-methylphenyl)propan-1-amine SUBSTANCE P (7-11) CEGABA

P-METHYLAMPHETAMINE SENKTIDE ANALOG (5-11),SENKTIDE ANALOG,NH2-SENKTIDE METHYL-(2-P-TOLYL-ETHYL)-AMINE SENKTIDE

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succinyl(asp6 Substance P, fragment 6-11, succinyl[Asp6, NMePhe8] M.W. 842.1 C40H55N7O11S N-(3-Carboxy-1-oxopropyl)-L-Asp-L-Phe-N-methyl-L-Phe-Gly-L-Leu-L-Met-NH2 N-(3-Carboxy-1-oxopropyl)-L-αAsp-L-Phe-N-methyl-L-Phe-Gly-L-Leu-L-Met-NH2 Suc-[Asp6,MePhe8]substance P(6-11) [SUCCINYL-ASP6,ME-PHE8] SUBSTANCE P SUCCINYL-(ASP6,N-ME-PHE8)-SUBSTANCE P (6-11) [SUCCINYL-ASP6 N-ME-PHE8]-SUBSTANCE P (6-11) (SENKTIDE) [SUCCINYL-ASP6,N-ME-PHE8]-SUBSTANCE P, FRAGMENT 6-11 SUCCINYL-ASP-PHE-ME-PHE-GLY-LEU-MET-NH2 SUCCINYL-ASP-PHE-(N-ME)PHE-GLY-LEU-MET-NH2 SUCCINYL-ASP-PHE-N-METHYL-PHE-GLY-LEU-MET-NH2 SUC-ASP-PHE-N-ME-PHE-GLY-LEU-MET-NH2 SUC-[ASP6, N-ME-PHE8]-SUBSTANCE P (6-11) SUBSTANCE P SUCCINYL-[ASP6, N-ME-PHE8]-FRAGMENT 6-11 SUC-DF(ME)FGLM-NH2 SUC-DF-(NMEF)-GLM-NH2 SENKTIDE SENKTIDE (6-11) SELECTIVE NEUROKININ B RECEPTOR PEPTIDE DFFGLM (Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide) trifluoroacetate salt Senktide trifluoroacetate salt Suc-Asp-Phe-MePhe-Gly-Leu-Met-NH2 trifluoroacetate salt 4-10-Neuromedin B (swine spinal cord), N-(3-carboxy-1-oxopropyl)-6-(N-methyl-L-phenylalanine)-7-de-L-valine- L-Methioninamide, N-(3-carboxy-1-oxopropyl)-L-alpha-aspartyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl- N-(3-Carboxy-1-oxopropyl)-6-(N-methyl-L-phenylalanine)-7-de-L-valine-4-10-neuromedin B (swine spinal cord) Substance p (6-11), succinyl-Asp(6)-me-Phe(8)- Substance p (6-11), succinyl-aspartyl(6)-methylphenylalanine(8)- Succinyl-6-Asp-8-me-Phe-substance p (6-11) Senktide?, BR L-Methioninamide, N-(3-carboxy-1-oxopropyl)-L-α-aspartyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl- Senktide,Inhibitor,inhibit,Tachykinin receptor,NK receptor,Neurokinin Receptor Suc-Asp6, Me-Phe8] Substance P [Succinyl-Asp6, NMePhe8]-Substance P (6-11), Senktide - 5 mg 106128-89-6 C40H55N7O11S BioChemical Amino Acids and Peptides Agonist Biochemicals and Reagents Tachykinins Peptides peptide Tachykinin receptor