ChemicalBook >> CAS DataBase List >>2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
- CAS No.
- 150493-34-8
- Chemical Name:
- 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
- Synonyms
- NS 638;NS638, >98%;NS-638;NS 638;2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine;1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine;1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-;Ca channels,Inhibitor,NS-638,Calcium Channel,inhibit,Ca2+ channels,NS638;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638
- CBNumber:
- CB11344812
- Molecular Formula:
- C15H11ClF3N3
- Molecular Weight:
- 325.72
- MDL Number:
- MOL File:
- 150493-34-8.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:54:59
Boiling point | 476.3±55.0 °C(Predicted) |
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Density | 1.45±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol |
form | A solid |
pka | 5.15±0.10(Predicted) |
color | White to off-white |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
NFPA 704 |
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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-6337 | NS-638 >98.0% | 150493-34-8 | 2mg | $50 | 2021-12-16 | Buy |
ChemScene | CS-6337 | NS-638 >98.0% | 150493-34-8 | 5mg | $100 | 2021-12-16 | Buy |
ChemScene | CS-6337 | NS-638 >98.0% | 150493-34-8 | 10mg | $150 | 2021-12-16 | Buy |
ChemScene | CS-6337 | NS-638 >98.0% | 150493-34-8 | 25mg | $290 | 2021-12-16 | Buy |
ChemScene | CS-6337 | NS-638 >98.0% | 150493-34-8 | 50mg | $470 | 2021-12-16 | Buy |
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Chemical Properties,Uses,Production
Biological Activity
NS-638 is a non-peptidic small molecule with Ca2+-ion channel blocking properties. The IC50 value for intracellular blocking of the increase in Ca2+ concentration activated by K+ was 3.4 μM.
in vivo
In the mouse middle cerebral artery occlusion model, NS-638 administered ip (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.
target
IC50: 3.4 μM (K + -stimulated intracellular Ca 2+ -elevation)
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 48)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
150493-34-8(2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole)Related Search:
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
NS 638
1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-
1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine
NS-638;NS 638
NS638, >98%
1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine
1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638
Ca channels,Inhibitor,NS-638,Calcium Channel,inhibit,Ca2+ channels,NS638
150493-34-8