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Deslorelin

Deslorelin Structure
Deslorelin structure
CAS No.
57773-65-6
Chemical Name:
Deslorelin
Synonyms
H 4065;tryptal;somagard;Deslelin;DESORELIN;DESLORELIN;bachem9022;Deslorenlin;Deslelin Acetate;DESLORELIN, >99%
CBNumber:
CB1144228
Molecular Formula:
C64H83N17O12
Molecular Weight:
1282.48
MDL Number:
MFCD00167401
MOL File:
57773-65-6.mol
MSDS File:
SDS
Last updated:2024-10-25 16:21:11
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Deslorelin Properties

Melting point >189oC
alpha D24 -61° (c = 0.37 in 0.1M acetic acid)
Density 1.48±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility Acetic acid (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka 9.82±0.15(Predicted)
color White to Off-White
Sequence Pyr-His-Trp-Ser-Tyr-DTrp-Leu-Arg-Pro-NHEt
InChIKey GJKXGJCSJWBJEZ-QCOVUDKBNA-N
CAS DataBase Reference 57773-65-6(CAS DataBase Reference)
NCI Dictionary of Cancer Terms deslorelin
FDA UNII TKG3I66TVE
NCI Drug Dictionary deslorelin acetate

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P302+P352-P362+P364
Hazard Codes  T
Risk Statements  60
Safety Statements  53-22-36/37/39-45
WGK Germany  3
RTECS  OK6755000
HS Code  3504009000

Deslorelin price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological D3220-75 Deslorelin 57773-65-6 5mg $297 2021-12-16 Buy
Biosynth Carbosynth FD41614 Deslorelin acetate 57773-65-6 50mg $333 2021-12-16 Buy
Biorbyt Ltd orb364555 Deslorelin Acetate > 95% 57773-65-6 1mg $661.3 2021-12-16 Buy
Apolloscientific BITH3011 Deslorelin 57773-65-6 100mg $827 2021-12-16 Buy
American Custom Chemicals Corporation INB0002052 DESLORELIN 95.00% 57773-65-6 5MG $1010.05 2021-12-16 Buy
Product number Packaging Price Buy
D3220-75 5mg $297 Buy
FD41614 50mg $333 Buy
orb364555 1mg $661.3 Buy
BITH3011 100mg $827 Buy
INB0002052 5MG $1010.05 Buy

Deslorelin Chemical Properties,Uses,Production

Description

Deslorelin is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production.

Chemical Properties

White powder, tens of times more biologically active than natural LH-RH, is synthesized by solid-phase or liquid-phase synthesis method using the corresponding protected amino acid monomers as raw materials.

Uses

Induction of ovulation in estrous mares Reproduction control in dogs

Definition

ChEBI: Deslorelin is an oligopeptide.

brand name

Somagard [as acetate] (Roberts Pharmaceutical).

General Description

Deslorelin (brand names: SucroMate, Suprelorin F, Suprelorin 12, Suprelorin-6) is a synthetic hormone used to induce ovulation and manage artificial insemination programs in horses, modulate reproduction in dogs, or manage adrenal disease in ferrets. In the U.S., deslorelin is only FDA approved for use in mares and ferrets, and 'off label' or 'extra-label' use is prohibited at this time.

Side effects

The most common side effects include swelling, sensitivity, and redness or warmth at the injection site. Rarely reported side effects in dogs include prolonged estrus and uterine infections.

Veterinary Drugs and Treatments

Deslorelin is approved for inducing ovulation in estrual mares. There is also interest in developing dosages and dosage forms as a long-term, reversible contraceptive in a variety of animal species, as a treatment for prostatic disease in male dogs, and incontinence in ovariectomized dogs. At the time of writing, deslorelin in not available in the USA, but is marketed in Canada.
In humans, deslorelin has been investigated for treating children with precocious puberty, and in adults for prostate carcinoma, dysmenorrhea, fibroids, and endometriosis.

References

[1] CLAIRE GROSSET. Contraceptive effect and potential side-effects of deslorelin acetate implants in rats (Rattus norvegicus): preliminary observations.[J]. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2012, 76 3: 209-214.
[2] STEFANO ROMAGNOLI. Chronic Use of Deslorelin in Dogs: Six Cases (2005-2022).[J]. Animals, 2023, 13 2. DOI:10.3390/ani13020265.
[3] K E OERTER. Adult height in precocious puberty after long-term treatment with deslorelin.[J]. Journal of Clinical Endocrinology & Metabolism, 1991, 73 6: 1235-1240. DOI:10.1210/jcem-73-6-1235.

Deslorelin Preparation Products And Raw materials

Raw materials

2-Chlorotrityl chloride 1-Hydroxybenzotriazole Ethylamine hydrochloride N,N'-Diisopropylcarbodiimide

Preparation Products

Deslorelin Suppliers

Global( 279)Suppliers
Supplier Tel Email Country ProdList Advantage
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616 gksales1@gk-bio.com China 9315 58
Hubei Ipure Biology Co., Ltd
+8613367258412 ada@ipurechemical.com China 10319 58
qingdao future trading Co., Ltd
+86-13335044410 +86-13335044410 cui56813@163.com China 110 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 49979 58
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8817 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12837 58
Shanghai Yunao International Trade Co., Ltd 		+8617621705551 asdf@shanghaihg.cn China 264 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
Shandong Huisheng Import & Export Co., Ltd. 		+86-13176845580 +86-13176845580 da@zhongda-biotech.com China 232 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Supplier Advantage
Baoji Guokang Bio-Technology Co., Ltd.
58
Hubei Ipure Biology Co., Ltd
58
qingdao future trading Co., Ltd
58
GIHI CHEMICALS CO.,LIMITED
58
Hebei Weibang Biotechnology Co., Ltd 		58
Hebei Mojin Biotechnology Co., Ltd 		58
Shanghai Yunao International Trade Co., Ltd 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Shandong Huisheng Import & Export Co., Ltd. 		58
Anhui Ruihan Technology Co., Ltd 		58

View Lastest Price from Deslorelin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Deslorelin pictures 2024-11-01 Deslorelin
57773-65-6
 US $30.00 / box 1box 99% 2000kg hebei hongtan Biotechnology Co., Ltd
Deslorelin Acetate pictures 2024-11-01 Deslorelin Acetate
57773-65-6
 US $500.00-0.00 / g 0.1g 98%+ 100kgs Wuhan Nutra Biotechnology Co.,Ltd
Deslorelin pictures 2024-10-25 Deslorelin
57773-65-6
 US $1.00 / KG 1KG 99% 10 mt Hebei Weibang Biotechnology Co., Ltd
  • Deslorelin pictures
  • Deslorelin
    57773-65-6
  • US $30.00 / box
  • 99%
  • hebei hongtan Biotechnology Co., Ltd
  • Deslorelin pictures
  • Deslorelin
    57773-65-6
  • US $1.00 / KG
  • 99%
  • Hebei Weibang Biotechnology Co., Ltd

57773-65-6(Deslorelin)Related Search:

Glatiramer acetate POLY(VINYL ACETATE) Ammonium acetate Cellulose acetate Sodium acetate
Vinyl acetate Ethyl acetate ACETATE Triptorelin L-Prolinamide
D(+)-Tryptophan meterelin PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-LEU-ARG-PRO-GLY-NH2 Luteinizing Hormone Releasing Hormone (LHRH) [des-Gly10, D-Trp6, Pro-NHEt9] (human) (Deslorelin) Lutrelin
Deslorelin LHRH(DES-GLY10,D-TRP6,PRO-NHET9),DESLORELIN,RABBITANTI-HUMAN:IH Deslorelin, LHRH (Des-Gly10,D-Trp6,Pro-NHEt9), Rabbit anti-Human, IF Kit

1of4

Deslorelin,Deslorelin acetate GLP-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET [D-TRP6, DES-GLY10]-LH-RH ETHYLAMIDE DESORELIN DESLORELIN deslorelin acetate DESLORELIN (HUMAN) DES-GLY10,[D-TRP6]-LH-RH ETHYLAMIDE (DES-GLY10,D-TRP6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE (DES-GLY10,D-TRP6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE (SEA BREAM) (DES-GLY10,D-TRP6,PRO-NHET9)-LHRH [DES-GLY10, D-TRP6, PRO-NHET9]-LH-RH (HUMAN) (DES-GLY10,D-TRP6,PRO-NHET9)-LHRH (SEA BREAM) (DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR (DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR (SEA BREAM) (DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE [DES-GLY10, D-TRP6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE HUMAN (DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE (SEA BREAM) des-gly10,(D-trp6)luteinizing hormone*releasing H DES-GLY10,(D-TRP6)LUTEINIZING HORMONE*RE LEASING HOR 1-9-Luteinizing hormone-releasing factor (swine), 6-D-tryptophan-9-(N-ethyl-L-prolinamide)- PYROGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO NHCH2CH3 PYROGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NH-ETHYL PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET PGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET luteinizinghormone-releasingfactor(pig),6-d-tryptophan-9-(n-ethyl-l-prolina mide)-10-deglycinamide- somagard tryptal (Des-Gly10，D-Trp6，Proethylamide9)-LRF luteinizing hormone releasing hormone (D-Trp^<6^>) analog Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt acetate salt Delorelin acetate (d-trp(sub6)-pro(sup9)-net)-gnrh (d-trp(sub6)-pro(sup9)-net)-gonadotropinreleasinghormone (d-trp(sup6)-pro(sup9))-lhrhethylamide (d-trp(sup6)-pro(sup9))-luteinizinghormone-releasinghormoneethylamide (d-trp(sup6)-pro(sup9)-net)-gonadotropinreleasinghormon bachem9022 d-trp(sup6)-pro(sup9)-n-ethylamide-lhrh (Des-Gly10,D-Trp6,Pro-NHEt9)-LHRH High acetate salt Deslorelin High acetate salt Deslorelin High acetate salt Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt High acetate salt Deslorenlin Deslelin Acetate H 4065 DESLORELIN, >99% Deslorelin,H 4065, >99% Deslorelin Acetate / Deslorelin Deslorelin impurity Injectable Lyophillzed Powder Peptides Peptide Deslorelin CAS 57773-65-6 To los gonadorelin Deslorelin USP/EP/BP Deslorelin，H 4065 Deslelin Deslorelin Acetate(net) Deserelin acetate 57773-65-6