Teneligliptin
- CAS No.
- 760937-92-6
- Chemical Name:
- Teneligliptin
- Synonyms
- Teliglietin;teneligliptin;Teneligptin WS;Teneligliptin (MP-513);API (Teneligliptin free base);3-[[(2S,4R)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine;3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine;Methanone,[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-;[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone;((2S,4S)-4-(4-(3-Methyl-1-phenyl1H-pyrazol-5-yl)piperazin-1yl)pyrrolidin-2-yl)(thiazolidin-3yl)methanone hydrobromide hydrate
- CBNumber:
- CB11518541
- Molecular Formula:
- C22H30N6OS
- Molecular Weight:
- 426.58
- MDL Number:
- MFCD13195565
- MOL File:
- 760937-92-6.mol
| Melting point | >100°C (dec.) |
|---|---|
| Boiling point | 663.4±55.0 °C(Predicted) |
| Density | 1.38 |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.70±0.10(Predicted) |
| color | Off-White |
| InChIKey | WGRQANOPCQRCME-PMACEKPBSA-N |
| SMILES | C([C@@H]1C[C@H](N2CCN(C3N(C4=CC=CC=C4)N=C(C)C=3)CC2)CN1)(N1CCSC1)=O |
| FDA UNII | 28ZHI4CF9C |
| ATC code | A10BH08 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 |
Teneligliptin price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T018295 | Teneligliptin | 760937-92-6 | 10mg | $45 | 2021-12-16 | Buy |
| ChemScene | CS-0882 | Teneligliptin 99.57% | 760937-92-6 | 10mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-0882 | Teneligliptin 99.57% | 760937-92-6 | 50mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-0882 | Teneligliptin 99.57% | 760937-92-6 | 100mg | $288 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014166 | TENELIGLIPTIN 95.00% | 760937-92-6 | 5MG | $502.54 | 2021-12-16 | Buy |
Teneligliptin Chemical Properties,Uses,Production
Description
Teneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC50=0.37 nM).
Originator
Mitsubishi Tanabe Pharma (Japan)
Uses
Teneligliptin, is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.
Definition
ChEBI: Teneligliptin is an amino acid amide.
brand name
Tenelia
Pharmacokinetics
Reported evidence suggests that with teneligliptin 20 mg therapy, Tmax was 1 hour, and t1/2 was 18.9 hours. Maximum (89.7%) inhibition in plasma DPP-4 activity was noted within 2 hours and maintained >60% at 24 hours. Compared to the placebo, active plasma GLP-1 concentration was higher throughout the day and even 24 hours after administration of 20 mg of teneligliptin. Metabolism of teneligliptin was majorly mediated through CYP3A4, a cytochrome P450 isozyme, and flavin-containing monooxygenases (FMO1 and FMO3). A weak inhibitory activity of teneligliptin on CYP2D6, CYP3A4, and FMO was noted, while there was no inhibitory activity on CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C8/9, CYP2C19, and CYP2E1. There was no induction of expression of CYP1A2 or CYP3A4. Reported evidence suggests that teneligliptin is metabolized and eliminated via renal and hepatic routes. Approximately 34% of teneligliptin is excreted unchanged via the renal route, while 66% is metabolized and eliminated via the hepatic and renal routes[1].
Side effects
The DPP-4 molecule in teneligliptin reduces the risk of hypoglycemia, although it is possible. These are some of teneligliptin’s major and minor side effects:
Hypoglycemia
Headache
Upper respiratory tract infection
Gastrointestinal symptoms
Constipation
Fatigue
Kidney problems
Nasopharyngitis
Skin rashes
Itching
Loss of appetite
Abdominal pain
References
[1] Surendra Kumar Sharma. “Teneligliptin in management of type 2 diabetes mellitus.” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 9 (2016): 251–60.
Teneligliptin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemExpress | +86-021-58950125 +86-021-58950125; | info@chemexpress.com | China | 781 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 340 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2251 | 58 |
Related articles
- Teneligliptin: Indications, Mechanism of Action and Side Effects
- Teneligliptin is a novel third-generation DPP-4 inhibitor approved for the treatment of type II diabetes. The compound has a u....
- Dec 16，2024
View Lastest Price from Teneligliptin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-26 | Teneligliptin
760937-92-6
|
US $0.00-0.00 / kg | 1kg | 99%, Single impurity＜0.1 | 1 ton | Nanjing Fred Technology Co., Ltd | |
 |
2024-11-19 | Teneligliptin
760937-92-6
|
US $0.00-44.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2022-09-16 | Teneligliptin
760937-92-6
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Teneligliptin
760937-92-6
- US $0.00-0.00 / kg
- 99%, Single impurity＜0.1
- Nanjing Fred Technology Co., Ltd
-
- Teneligliptin
760937-92-6
- US $0.00-44.00 / mg
- TargetMol Chemicals Inc.
-
- Teneligliptin
760937-92-6
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.