4-METHOXYCINNAMIC ACID
- CAS No.
- 943-89-5
- Chemical Name:
- 4-METHOXYCINNAMIC ACID
- Synonyms
- PMCA;AKOS B000181;AKOS BB/0034;AKOS BBS-00000769;TIMTEC-BB SBB005717;RARECHEM BK HC T257;OTAVA-BB BB0123400502;4-Methoxycinnamic acid;LABOTEST-BB LT00108121;O-METHYL-P-CUMARIC ACID
- CBNumber:
- CB1152939
- Molecular Formula:
- C10H10O3
- Molecular Weight:
- 178.18
- MDL Number:
- MFCD00004398
- MOL File:
- 943-89-5.mol
- MSDS File:
- SDS
| Melting point | 173.5 °C(lit.) |
|---|---|
| Boiling point | 342.6±17.0 °C(Predicted) |
| Density | 1.195±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in ethanol, ethyl acetate and other organic solvents. |
| pka | 4.60±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 510468 |
| InChIKey | AFDXODALSZRGIH-QPJJXVBHSA-N |
| LogP | 1.264 (est) |
| CAS DataBase Reference | 943-89-5(CAS DataBase Reference) |
| FDA UNII | 6G4ML8401A |
| NIST Chemistry Reference | 2-Propenoic acid, 3-(4-methoxyphenyl)-, (e)-(943-89-5) |
| EPA Substance Registry System | 2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)- (943-89-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UD3391300 | |||||||||
| F | 8 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2918.29.7500 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
4-METHOXYCINNAMIC ACID price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M0576 | trans-4-Methoxycinnamic Acid >98.0%(GC)(T) | 943-89-5 | 25g | $31 | 2024-03-01 | Buy |
| TCI Chemical | M0576 | trans-4-Methoxycinnamic Acid >98.0%(GC)(T) | 943-89-5 | 100g | $77 | 2024-03-01 | Buy |
| Alfa Aesar | A13870 | trans-4-Methoxycinnamic acid 98% | 943-89-5 | 10g | $21.65 | 2024-03-01 | Buy |
| Alfa Aesar | A13870 | trans-4-Methoxycinnamic acid 98% | 943-89-5 | 50g | $80.65 | 2024-03-01 | Buy |
| Alfa Aesar | A13870 | trans-4-Methoxycinnamic acid 98% | 943-89-5 | 250g | $336.65 | 2024-03-01 | Buy |
4-METHOXYCINNAMIC ACID Chemical Properties,Uses,Production
Uses
Esters derived from trans-4-methoxycinnamic acid are effective absorbers of UV radiation. The starting material was trans-4-methoxycinnamic acid and 3,5dimethoxybenzoic acid methyl ester in isolated avenanthramide alkaloids synthsis. trans-4-Methoxycinnamic acid was converted into its acid chloride (yield 98%) with thionyl chloride. Employed in organic synthesis of pharmaceutical intermediates, synthetic anti-adrenergic drugs esmolol, cosmetics ultraviolet absorption.
Preparation
4-methoxycinnamic acid synthesis : In a 25-mL, roundbottomed flask, 4-methoxybenzaldehyde (0.804 mL, 6.61 mmol) (3), malonic acid (1.75 g, 16.8 mmol), and β-alanine (0.10 g, 1.12 mmol) were dissolved in pyridine (3.0 mL, 37.1 mmol) and heated under reflux for 90 minutes. After cooling to room temperature, the reaction mixture was placed in an ice bath and 8.0 mL of concentrated HCl was slowly added. The resulting white precipitate was collected by vacuum filtration, washed with cold water (2 x 10mL) and dried thoroughly. The product was recrystallized from absolute ethanol (~20 mL).
Synthesis of 4-methoxycinnamic acid
Definition
ChEBI: 4-methoxycinnamic acid is a methoxycinnamic acid having a single methoxy substituent at the 4-position on the phenyl ring. It is functionally related to a cinnamic acid.
Purification Methods
Crystallise the acid from MeOH to constant melting point and UV spectrum. [Beilstein 10 IV 1005.]
4-METHOXYCINNAMIC ACID Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Dalian Richfortune Chemicals Co., Ltd | 0411-84820922 8613904096939 | sales@richfortunechem.com | China | 304 | 57 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3003 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
View Lastest Price from 4-METHOXYCINNAMIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-29 | 4-METHOXYCINNAMIC ACID
943-89-5
|
US $0.10 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2023-03-27 | 4-methoxycinnamicacid
943-89-5
|
US $25.00 / KG | 1KG | 0.99 | 20 tons | XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD | |
 |
2021-08-12 | 4-METHOXYCINNAMIC ACID
943-89-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 4-METHOXYCINNAMIC ACID
943-89-5
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-methoxycinnamicacid
943-89-5
- US $25.00 / KG
- 0.99
- XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
-
- 4-METHOXYCINNAMIC ACID
943-89-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd