Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>CLOXAZOLAM

CLOXAZOLAM

CLOXAZOLAM Structure
CLOXAZOLAM structure
CAS No.
24166-13-0
Chemical Name:
CLOXAZOLAM
Synonyms
cs370;Enadel;CS 370;Betavel;Lubalix;Olcadil;Sepazon;Sepazone;mt14-411;Tolestan
CBNumber:
CB1157873
Molecular Formula:
C17H14Cl2N2O2
Molecular Weight:
349.21
MDL Number:
MFCD00868152
MOL File:
24166-13-0.mol
Last updated:2023-05-04 17:34:36

CLOXAZOLAM Properties

Melting point 202-204° (dec)
Boiling point 172°C (rough estimate)
Density 1.4125 (rough estimate)
refractive index 1.6100 (estimate)
pka 12.70±0.40(Predicted)
CAS DataBase Reference 24166-13-0
FDA UNII GYL649Z0HY
ATC code N05BA22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H336-H302+H312+H332
Precautionary statements  P261-P271-P304+P340-P312-P403+P233-P405-P501
RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 in mice (g/kg): 3.3 orally; >2.0 i.p. (Kamioka)

CLOXAZOLAM Chemical Properties,Uses,Production

Originator

Sepazon,Sankyo,Japan,1974

Uses

CLOXAZOLAM is a benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. It is metabolized into the active metabolite Delorezepam (D230675). Controlled Subs tance.

Definition

ChEBI: Cloxazolam is an oxazolobenzodiazepine and a hemiaminal ether.

Manufacturing Process

As described in US Patent 3,772,371: To a solution of 5.8 g of 5-chloro-2- bromoacetylamino-o-chlorobenzophenone in 120 ml of ethanol were added 0.95 g of ethanolamine and 1.3 g of sodium acetate. The resulting mixture was heated under reflux for 16 hours.
After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off to give 3.25 g of the desired product melting at 202° to 204°C with decomposition.

Therapeutic Function

Tranquilizer

CLOXAZOLAM Preparation Products And Raw materials

Raw materials

Monoethanolamine

Preparation Products

24166-13-0(CLOXAZOLAM)Related Search:

mexazolam 2-amino-5-chloro-diphenyl methanol CLOXAZOLAM N-Methyl 4-chloro-2-(methoxymethyl)aniline (3-chlorophenyl)(phenyl)methylamine
Dihydrochloride 4,5-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE (5-Chloro-2-(methylamino)phenyl)methanol (R,S)-1,3,4,5-TETRAHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE HYDROCHLORIDE 2-(2-HYDROXYETHYLAMINO)-N-(4-CHLOROPHENYL)ACETAMIDE
7-CHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE 2-AMINOBENZHYDROL C-(3-CHLORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE (2-chlorophenyl)(phenyl)methylamine
2-(AMINOMETHYL)-4-CHLORO-N-METHYLBENZENAMINE C-(2-CHLORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE

1of4

Sepazone 10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one CLOXAZOLAM 10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one 10-Chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-oxazolo[3,2-d] [1,4]benzodiazepin-6(5H)-one 11b-tetrahydro- Betavel Cloxazolazepam CS 370 cs370 Enadel Lubalix MT 14-411 mt14-411 Olcadil Oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one, 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro- oxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one,10-chloro-11b-(o-chlorophenyl)-2,3, Sepazon Tolestan Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro- Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro- (8CI) 10-chloro-11b-(2-chlorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one CLOXAZOLAM USP/EP/BP 24166-13-0 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals