MYCALOLIDE B
- CAS No.
- 122752-21-0
- Chemical Name:
- MYCALOLIDE B
- Synonyms
- MYCALOLIDE B;Mycalolide B, Mycale sp.;MYCALOLIDE B, MYCALE SPECIES;4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C;Propanoic acid, 2,3-dimethoxy-, (1R,2S,3R,4R,5E)-3-(acetyloxy)-6-(formylmethylamino)-1-[(3S,4S)-5-[(10S,11R,13E,16S,20S,21R,22S,24E)-16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-2(31),4,6(30),8,13,24,26(29),28-octaen...
- CBNumber:
- CB1196858
- Molecular Formula:
- C52H74N4O17
- Molecular Weight:
- 1027.16
- MDL Number:
- MFCD34567089
- MOL File:
- 122752-21-0.mol
MYCALOLIDE B Chemical Properties,Uses,Production
Description
Mycalolide B (122752-21-0) is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM).1?It selectively and completely depolymerizes F-actin to G-actin?via?a novel mechanism different from that of the cytochalasin D.2?It is a novel and specific inhibitor of actomyosin ATPase.3
References
1) Saito et al. (1994), Mycalolide B, a novel actin depolymerizing agent; J. Biol. Chem., 269 29710 2) Sugidachi et al. (1998), Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D; Thromb. Haemost., 79 614 3) Hori et al. (1993), Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge; FEBS Lett., 322 151
MYCALOLIDE B Preparation Products And Raw materials
Raw materials
Preparation Products
MYCALOLIDE B Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94658 | 76 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Supplier | Advantage |
---|---|
Aladdin Scientific | 58 |
J & K SCIENTIFIC LTD. | 76 |
Shanghai EFE Biological Technology Co., Ltd. | 58 |