N-Methylleukotriene C4
- CAS No.
- 131391-65-6
- Chemical Name:
- N-Methylleukotriene C4
- Synonyms
- NMLTC4;N-METHYL LTC4;N-Methylleukotriene C4;FPLBRCJNODNRQZ-UYCXAPQFSA-N;N methyl Leukotriene C4,N-methyl Leukotriene C-4,Nmethyl Leukotriene C4;Glycine, N-methyl-L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl-;N-[S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-N-(L-γ-glutamyl)-L-cysteinyl]-N-methylglycine
- CBNumber:
- CB12192012
- Molecular Formula:
- C31H49N3O9S
- Molecular Weight:
- 639.81
- MDL Number:
- MFCD11113154
- MOL File:
- 131391-65-6.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
N-Methylleukotriene C4 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13390 | N-methyl Leukotriene C4 ≥97% | 131391-65-6 | 25μg | $165 | 2024-03-01 | Buy |
| Cayman Chemical | 13390 | N-methyl Leukotriene C4 ≥97% | 131391-65-6 | 50μg | $313 | 2024-03-01 | Buy |
| Cayman Chemical | 13390 | N-methyl Leukotriene C4 ≥97% | 131391-65-6 | 100μg | $592 | 2024-03-01 | Buy |
| TRC | L330388 | N-methylLeukotrieneC4 | 131391-65-6 | 2.5mg | $1235 | 2021-12-16 | Buy |
N-Methylleukotriene C4 Chemical Properties,Uses,Production
Uses
N-methyl Leukotriene C4 is synthetic analog of LTC4 with decreased binding affinity.
Uses
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.
N-Methylleukotriene C4 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |