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3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE structure

CAS No.: 562823-84-1

Chemical Name:: 3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE

Synonyms: MDM2-IN-20;MDM2 Inhibitor;TRANS-4-IODO,4'-BORANYL-CHALCONE;MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem;3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE;3-(4-IODO-PHENYL)-1-(4''- BORANYL-PHENYL)-PROP-2-ENONE (FOR R&D ONLY);Boronic acid, B-[4-[(2E)-3-(4-iodophenyl)-1-oxo-2-propen-1-yl]phenyl]-

CBNumber:: CB1219430

Molecular Formula:: C15H12BIO3

Molecular Weight:: 377.97

MDL Number:: MFCD06798340

MOL File:: 562823-84-1.mol

Last updated:2023-05-04 17:34:40

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3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Properties

storage temp.	+2C to +8C
solubility	DMSO: >30 mg/mL, soluble
form	solid

SAFETY

Risk and Safety Statements

WGK Germany	3

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	444145	MDM2 Inhibitor	562823-84-1	10mg	$181	2023-01-07	Buy
American Custom Chemicals Corporation	HCH0011875	3-(4-IODO-PHENYL)-1-(4'- BORANYL-PHENYL)-PROP-2-ENONE 95.00%	562823-84-1	10MG	$676.71	2021-12-16	Buy

Product number	Packaging	Price	Buy
444145	10mg	$181	Buy
HCH0011875	10MG	$676.71	Buy

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Chemical Properties,Uses,Production

Definition

ChEBI: [4-[3-(4-iodophenyl)prop-2-enoyl]phenyl]boronic acid is a member of chalcones.

General Description

A cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC₅₀ = 10 μM for MDA-MB-435, 8.8 μM for MDA-MB-231, and 7 μM for Wt-MCF7) compared to normal breast cell lines (IC₅₀ = 75 μM for MCF-10A and 63 μM for MCF-12A).

Biochem/physiol Actions

Cell permeable: yes

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Preparation Products And Raw materials

Raw materials

Preparation Products

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Suppliers

Global( 16)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Haohong Scientific Co., Ltd.	400-400-8210725	malulu@leyan.com	China	40041	58
Yantai Lianhua Technology Co., Ltd	15552437730	1701654643@qq.com	China	10832	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	+86-18521732826	market@aladdin-e.com	China	48467	58

Supplier	Advantage
Aladdin Scientific	58
Sigma-Aldrich	80
Shanghai Haohong Scientific Co., Ltd.	58
Yantai Lianhua Technology Co., Ltd	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	58

562823-84-1(3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE)Related Search:

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE 4-Carboxyphenylboronic acid

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE 3-(4-IODO-PHENYL)-1-(4''- BORANYL-PHENYL)-PROP-2-ENONE (FOR R&D ONLY) TRANS-4-IODO,4'-BORANYL-CHALCONE MDM2 Inhibitor MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem Boronic acid, B-[4-[(2E)-3-(4-iodophenyl)-1-oxo-2-propen-1-yl]phenyl]- MDM2-IN-20 562823-84-1 C15H12BIO3 Cell Cycle RegulatorsImmune Cell Signaling and Blood Apoptosis and Cell Cycle Cell Cycle Immune System Regulation Immunomodulators and Antibiotics