QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER
- CAS No.
- 1247-97-8
- Chemical Name:
- QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER
- Synonyms
- PENTAMETHYLQUERCETIN;Pentamethoxyquercetin;QUERCETIN-3,5,7,3',4';QUERCETINPENTAMETHYLETHER;Rutoside Trihydrate Impurity 5;3,3',4',5,7-Pentamethoxyflavone;3,5,7,3',4'-PENTAMETHOXYFLAVONE;QUERCETIN-3,7-DIMETHYLETHER(RG);Quercetin-3,5,7,3',4'-pentamethylether;QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER
- CBNumber:
- CB1226629
- Molecular Formula:
- C20H20O7
- Molecular Weight:
- 372.37
- MDL Number:
- MFCD01004607
- MOL File:
- 1247-97-8.mol
| Melting point | 152-156°C |
|---|---|
| Boiling point | 561.9±50.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| form | Solid |
| color | White to light brown |
| LogP | 2.370 (est) |
| FDA UNII | V6J41K636O |
QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0135217 | 3,5,7,3′,4′-Pentamethoxyflavone | 1247-97-8 | 5mg | $180 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0032041 | QUERCETIN-3,5,7,3',4'-PENTAMETHYLETHER 95.00% | 1247-97-8 | 10MG | $771.31 | 2021-12-16 | Buy |
| Arctom | CFN70262 | Quercetin3,5,7,3,4-pentamethylether ≥98% | 1247-97-8 | 10mg | $318 | 2021-12-16 | Buy |
QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER Chemical Properties,Uses,Production
Uses
3,5,7,3’,4’-Pentamethoxyflavone is a Ca2+ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases[1][2][4].
in vivo
3,5,7,3’,4’-Pentamethoxyflavone (22 mg/kg; twice daily; 6 weeks; p.o.) can promote the expression of eNOS and CSE proteins in middle-aged male rats, and regulate vascular function by antagonizing the contraction of phenylephrine and enhancing the vasodilation of acetylcholine[4].
| Animal Model: | Middle-aged (12–14 month old) Wistar male rats[4]. |
| Dosage: | 22 mg/kg |
| Administration: | Oral gavage (p.o.); twice daily; 6 weeks |
| Result: | Caused a decrease in plasma glucose and an increase in plasma HDL cholesterol levels of the rats. |
References
[1] Jakhar R, et al. 3,5,7,3',4'-pentamethoxyflavone, a quercetin derivative protects DNA from oxidative challenges: potential mechanism of action. J Photochem Photobiol B. 2014 Feb 5;131:96-103. DOI:10.1016/j.jphotobiol.2014.01.003
[2] Jansakul C, et al. Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum. Eur J Pharmacol. 2012 Sep 15;691(1-3):235-44. DOI:10.1016/j.ejphar.2012.07.019
[3] Mayangsari Y, et al. 3,5,7,3',4'-Pentamethoxyflavone Enhances the Barrier Function through Transcriptional Regulation of the Tight Junction in Human Intestinal Caco-2 Cells. J Agric Food Chem. 2021 Sep 8;69(35):10174-10183. DOI:10.1021/acs.jafc.1c04295
[4] Yorsin S, et al. Increased vascular eNOS and cystathionine-γ-lyase protein after 6 weeks oral administration of 3, 5, 7, 3', 4'-pentamethoxyflavone to middle-aged male rats. Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1183-1194. DOI:10.1007/s00210-016-1280-0
QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3883 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9642 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49984 | 58 |
| Weifang Wehibest Supply Chain Co.,Ltd | +8613583620690 | hotspotbiotech@163.com | China | 926 | 58 |
View Lastest Price from QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-14 | 3,5,7,3′,4′-Pentamethoxyflavone
1247-97-8
|
US $198.00-123.00 / mg | 98.87% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-08-08 | 3,3',4',5,7-Pentamethoxyflavone
1247-97-8
|
US $0.00-0.00 / KG | 1KG | 99% | 1000Kg | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-02-11 | Quercetin-3,5,7,3',4'-pentamethylether
1247-97-8
|
US $9.80 / KG | 1g | ＞98% | 20 tons | Career Henan Chemical Co |
-
- 3,5,7,3′,4′-Pentamethoxyflavone
1247-97-8
- US $198.00-123.00 / mg
- 98.87%
- TargetMol Chemicals Inc.
-
- 3,3',4',5,7-Pentamethoxyflavone
1247-97-8
- US $0.00-0.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Quercetin-3,5,7,3',4'-pentamethylether
1247-97-8
- US $9.80 / KG
- ＞98%
- Career Henan Chemical Co
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