3',4',5,7-TETRAMETHOXYFLAVONE
- CAS No.
- 855-97-0
- Chemical Name:
- 3',4',5,7-TETRAMETHOXYFLAVONE
- Synonyms
- Methoxyluteolin;Tetramethylluteolin;Tetramethoxyluteolin;Luteolinetetramethylether;LUTEOLIN TETRAMETHYL ETHER;LUTEOLIN TETRAMETHYLETHER(RG);5,7,3’,4’-tetramethylluteolin;3',4',5,7-Tetramethoxyflavone;5,7,3',4'-Tetramethoxyflavone;Rutoside Trihydrate Impurity 6
- CBNumber:
- CB2197610
- Molecular Formula:
- C19H18O6
- Molecular Weight:
- 342.34
- MDL Number:
- MFCD00017558
- MOL File:
- 855-97-0.mol
- MSDS File:
- SDS
| Melting point | 195-197°C |
|---|---|
| Boiling point | 528.8±50.0 °C(Predicted) |
| Density | 1.243±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | DMSO:6.85(Max Conc. mg/mL);20.0(Max Conc. mM) |
| form | Solid |
| color | White to off-white |
| BRN | 336320 |
| LogP | 3.360 (est) |
| CAS DataBase Reference | 855-97-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| NFPA 704 |
|
3',4',5,7-TETRAMETHOXYFLAVONE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | L14496 | 3',4',5,7-Tetramethoxyflavone, 97% | 855-97-0 | 100mg | $68.65 | 2024-03-01 | Buy |
| Alfa Aesar | L14496 | 3',4',5,7-Tetramethoxyflavone, 97% | 855-97-0 | 500mg | $236.65 | 2024-03-01 | Buy |
| TRC | T298905 | 3,4,5,7-Tetramethoxyflavone | 855-97-0 | 50mg | $65 | 2021-12-16 | Buy |
| TRC | T298905 | 3,4,5,7-Tetramethoxyflavone | 855-97-0 | 10mg | $45 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT65917 | 3',4',5,7-Tetramethoxyflavone | 855-97-0 | 50mg | $40 | 2021-12-16 | Buy |
3',4',5,7-TETRAMETHOXYFLAVONE Chemical Properties,Uses,Production
Uses
5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1].
in vivo
5,7,3',4'-Tetramethoxyflavone (25-100 mg/kg, i.g.) exhibits chondroprotective activity in rats[1].
5,7,3',4'-Tetramethoxyflavone (5-20 mg/kg; i.v., p.o.) has the absolute bioavailability of 14.3 % in rats[3].
Pharmacokinetic Analysis in Sprague-dawley Rats Model[3]
| Route | Dose (mg/kg) | AUC (min μg/mL) | AUC/Dose (min/mL) | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | Bioavailability (%) |
| i.v. | 5 | 161.49 ± 58.78 | 0.1154 ± 0.0420 | 62.85 ± 27.92 | / | / | 14.3 |
| p.o. | 50 | 231.43 ± 71.87 | 0.0165 ± 0.0051 | 273.76 ± 90.23 | 190.34 ± 24.50 | 0.79 ± 0.30 | / |
| Animal Model: | Rat knee OA model[1] |
| Dosage: | 25-100 mg/kg |
| Administration: | i.g. |
| Result: | Decreased the contents of IL-1b, TNF-a, and PGE2 in a dose-dependent manner. Decreases the expression of the inflammatory cytokines in rat knee osteoarthritis (OA) synovial fluid (SF) lavages. Inhibited chondrocytes hypertrophy and decreased the cartilage thickness. Exhibited down regulation of b-catenin in a dose-dependent manner. |
IC 50
Plasmodium
storage
Store at -20°C
References
[1] Wu L, et al. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling in vivo and in vitro. Biochem Biophys Res Commun. 2014 Sep 26;452(3):682-8. DOI:10.1016/j.bbrc.2014.08.129
[2] Wu L, et al. 5,7,3',4'-Tetramethoxyflavone protects chondrocytes from ER stress-induced apoptosis through regulation of the IRE1α pathway. Connect Tissue Res. 2018 Mar;59(2):157-166. DOI:10.1080/03008207.2017.1321639
[3] Wei G, et al. Absolute bioavailability, pharmacokinetics and excretion of 5,7,30 ,40 -tetramethoxyflavone
3',4',5,7-TETRAMETHOXYFLAVONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10244 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9642 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
View Lastest Price from 3',4',5,7-TETRAMETHOXYFLAVONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | 3',4',5,7-TETRAMETHOXYFLAVONE
855-97-0
|
US $1.00 / KG | 1KG | 98% HPLC | 10t | Career Henan Chemical Co |
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- 3',4',5,7-TETRAMETHOXYFLAVONE
855-97-0
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co
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