ChemicalBook >> CAS DataBase List >>CAY10597

CAY10597

CAY10597 structure

CAS No.: 916046-55-4

Chemical Name:: CAY10597

Synonyms: CAY10597;2-(5-chloro-1'-(2-fluorobenzyl)-2,2',5'-trioxospiro[indoline-3,3'-pyrrolidin]-1-yl)acetic acid;5-CHLORO-1'-[(2-FLUOROPHENYL)METHYL]-2,2',5'-TRIOXO-SPIRO[3H-INDOLE-3,3'-PYRROLIDINE-1(2H)-ACETIC ACID];Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-

CBNumber:: CB12468603

Molecular Formula:: C20H14ClFN2O5

Molecular Weight:: 416.79

MDL Number:: MFCD11976898

MOL File:: 916046-55-4.mol

Last updated:2023-05-21 10:59:17

Request For Quotation

CAY10597 Properties

storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.30 mg/ml
form	A crystalline solid

CAY10597 price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	10012539	CAY10597 ≥98%	916046-55-4	1mg	$71	2024-03-01	Buy
Cayman Chemical	10012539	CAY10597 ≥98%	916046-55-4	5mg	$313	2024-03-01	Buy
Cayman Chemical	10012539	CAY10597 ≥98%	916046-55-4	10mg	$554	2024-03-01	Buy
AK Scientific	1448AH	5-Chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3h-indole-3,3'-pyrrolidine-1(2H)-aceticacid	916046-55-4	1mg	$176	2021-12-16	Buy

Product number	Packaging	Price	Buy
10012539	1mg	$71	Buy
10012539	5mg	$313	Buy
10012539	10mg	$554	Buy
1448AH	1mg	$176	Buy

CAY10597 Chemical Properties,Uses,Production

Description

The biological effects of prostaglandin D₂ (PGD₂) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP₁ and CRTH2/DP₂. In humans, CRTH2/DP₂ is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD₂. CAY10597, as a racemic mixture, is a potent CRTH2/DP₂ receptor antagonist that binds to the human receptor with a K_i value of 37 nM. The R enantiomer is slightly more potent exhibiting K_i values of 23 and 22 nM at the human and murine CRTH2/DP₂ receptor, respectively. The R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-prostaglandin D₂ with an IC₅₀ value of 40 nM.

CAY10597 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10597 Suppliers

Global( 19)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	0571-85361029	synstar518@163.com	China	1991	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8739	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28091	58

Supplier	Advantage
Shanghai Hongye Biotechnology Co. Ltd	58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58

5-CHLORO-1'-[(2-FLUOROPHENYL)METHYL]-2,2',5'-TRIOXO-SPIRO[3H-INDOLE-3,3'-PYRROLIDINE-1(2H)-ACETIC ACID] CAY10597 2-(5-chloro-1'-(2-fluorobenzyl)-2,2',5'-trioxospiro[indoline-3,3'-pyrrolidin]-1-yl)acetic acid Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo- 916046-55-4 C20H14ClFN2O5