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CAY10597

CAY10597 구조식 이미지

카스 번호:: 916046-55-4

상품명:: CAY10597

동의어(영문):: CAY10597;2-(5-chloro-1'-(2-fluorobenzyl)-2,2',5'-trioxospiro[indoline-3,3'-pyrrolidin]-1-yl)acetic acid;5-CHLORO-1'-[(2-FLUOROPHENYL)METHYL]-2,2',5'-TRIOXO-SPIRO[3H-INDOLE-3,3'-PYRROLIDINE-1(2H)-ACETIC ACID];Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-

CBNumber:: CB12468603

분자식:: C20H14ClFN2O5

포뮬러 무게:: 416.79

MOL 파일:: 916046-55-4.mol

속성

안전

용도

공급 업체 19

CAY10597 속성

저장 조건: Store at -20°C

용해도: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.30 mg/ml

물리적 상태: 결정성 고체

안전

CAY10597 C화학적 특성, 용도, 생산

개요

The biological effects of prostaglandin D₂ (PGD₂) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP₁ and CRTH2/DP₂. In humans, CRTH2/DP₂ is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD₂. CAY10597, as a racemic mixture, is a potent CRTH2/DP₂ receptor antagonist that binds to the human receptor with a K_i value of 37 nM. The R enantiomer is slightly more potent exhibiting K_i values of 23 and 22 nM at the human and murine CRTH2/DP₂ receptor, respectively. The R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-prostaglandin D₂ with an IC₅₀ value of 40 nM.

CAY10597 준비 용품 및 원자재

원자재

준비 용품

CAY10597 공급 업체

글로벌( 19)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	0571-85361029	synstar518@163.com	China	1991	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24647	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11975	58