ChemicalBook >> CAS DataBase List >>[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride

[S-(R,R)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride

[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride structure

CAS No.: 1243259-19-9

Chemical Name:: [S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride

Synonyms: LM11A-31;LM11A-31 BHS;LM11A-31 HCl;LM11A 31 2HCl;(2S,3S)-2-AMINO-3-;LM11A-31 (hydrochloride);LM11A-31 D8 dihydrochloride;LM11A-31 dihydrochloride salt;LM11A-31 dihydrochloride (LM11A-31 BHS);(2S,3S)-2-AMINO-3-METHYL-N-(2-MORPHOLIN-4-YLETHYL)PENTANAMIDE

CBNumber:: CB12621190

Molecular Formula:: C12H26ClN3O2

Molecular Weight:: 279.81

MDL Number:: MFCD11505486

MOL File:: 1243259-19-9.mol

Last updated:2023-06-30 15:45:59

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[S-(R,R)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride Properties

Melting point	>68°C (dec.)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 30 mg/ml)
form	solid
color	Pale yellow
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

HS Code	9999999999

[S-(R,R)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21982	LM11A-31 (hydrochloride) ≥98%	1243259-19-9	5mg	$50	2024-03-01	Buy
Cayman Chemical	21982	LM11A-31 (hydrochloride) ≥98%	1243259-19-9	10mg	$89	2024-03-01	Buy
Cayman Chemical	21982	LM11A-31 (hydrochloride) ≥98%	1243259-19-9	25mg	$172	2024-03-01	Buy
Cayman Chemical	21982	LM11A-31 (hydrochloride) ≥98%	1243259-19-9	50mg	$268	2024-03-01	Buy
TRC	A612500	(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamideHydrochloride	1243259-19-9	50mg	$90	2021-12-16	Buy

Product number	Packaging	Price	Buy
21982	5mg	$50	Buy
21982	10mg	$89	Buy
21982	25mg	$172	Buy
21982	50mg	$268	Buy
A612500	50mg	$90	Buy

[S-(R,R)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride Chemical Properties,Uses,Production

Description

LM11A-31 is a p75 neurotrophin receptor (p75^NTR) ligand that inhibits nerve growth factor (NGF) binding to p75^NTR-Fc (A₂ = 1,192 nM). It inhibits DNA damage in and promotes survival of hippocampal neuronal cultures in a p75^NTR- and concentration-dependent manner. LMA11A-31 also inhibits proNGF-induced cell death of mature oligodendrocytes. In vivo, LMA11A-31 (10-100 mg/kg) improves motor function and coordination in the weight-bearing open-field test and nonweight-bearing swim test and increases survival of oligodendrocytes in a mouse model of spinal contusion injury. It prevents and/or reverses atrophy of forebrain cholinergic neurites and cortical dystrophic neurites in Thy-1 hAPP^Lond/Swe and Tg2576 mice with mid- to late stage Alzheimer''s disease. It also reduces excessive alcohol self-administration in rats and decreases huntingtin (Htt) aggregate formation and striatal cholinergic degeneration in the R6/2 mouse model of Huntington''s disease.

Uses

(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide is used for the preparation of peptideamides for treatment of retroviral infection.

storage

Desiccate at RT

References

1) Massa?et al. (2006),?Small, Nonpeptide p75NTR Ligands Induce Survival Signaling and Inhibit proNGF-Induced Death; J. Neurosci.?26?5288 2) Tep?et al., (2013),?Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury; J. Neurosci.?33?397 3) Shi?et al. (2013),?A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury; Stem Cells?31?2561 4) Simmons?et al.?(2014),?A small molecule p75(NTR) ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer’s disease mouse models with mid- to late-stage disease progression; PLoS One?9?e102136 5) Meeker?et al.?(2016),?Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis; Exp. Neurol.?275?Pt.1 182

[S-(R,R)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

[S-(R,R)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride Suppliers

Global( 48)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	25961	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60

Supplier	Advantage
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
J & K SCIENTIFIC LTD.	76
Chemsky (shanghai) International Co.,Ltd	60

View Lastest Price from [S-(R,R)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-19	[S-(R,R)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride 1243259-19-9	US $1.00 / KG	1KG	99.0%	100kg	Career Henan Chemical Co

[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride
1243259-19-9
US $1.00 / KG
99.0%
Career Henan Chemical Co

1243259-19-9([S-(R,R)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride)Related Search:

Erlotinib hydrochloride 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE TYRPHOSTIN AG 879 LM 22A4

(2S,3S)-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Hydrochloride [S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride (2S,3S)-2-AMINO-3-METHYL-N-(2-MORPHOLIN-4-YLETHYL)PENTANAMIDE LM11A-31 Pentanamide, 2-amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-, hydrochloride (1:2), (2S,3S)- LM11A-31 (hydrochloride) (2S,3S)-2-Amino-3-methyl-N-(2-morpholinoethyl)pentanamide Dihydrochloride LM11A-31 dihydrochloride (LM11A-31 BHS) (2S,3S)-2-amino-3-methyl-N-(2-morpholinoethyl)pentanamide hydrochloride (2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride LM11A-31 BHS LM11A 31 2HCl LM11A-31 D8 dihydrochloride [S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride ISO 9001：2015 REACH LM11A-31 dihydrochloride salt (2S,3S)-2-AMINO-3- LM11A-31 HCl cholinergic,proNGF,Inhibitor,inhibit,growth,dystrophy,disease,p75,Neurotensin Receptor,LM-11A-31 dihydrochloride,nerve,neurite,receptor,barrier,neurotrophin,LM11A-31,factor,Ligand,LM11A 31 dihydrochloride,blood-brain,LM11A31 dihydrochloride,Alzheimer's,p75NTR 1243259-19-9 Amino Acids & Derivatives Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Amino Acids & Derivatives, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals

[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride

[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride Properties