2-Fluoro-4-nitrobenzoic acid
- CAS No.
- 403-24-7
- Chemical Name:
- 2-Fluoro-4-nitrobenzoic acid
- Synonyms
- NSC 190361;BUTTPARK 32\01-74;SALOR-INT L446572-1EA;Enzalutamide Impurity 25;2-Fluor-4-nitrobenzoic acid;2-Fluoro-4-nitrobenzotc acid;2-FLUORO-4-NITROBENZOIC ACID;2-chloro-4-nitrobenzoice acid;4-Carboxy-3-fluoronitrobenzene;Benzoicacid, 2-fluoro-4-nitro-
- CBNumber:
- CB1262658
- Molecular Formula:
- C7H4FNO4
- Molecular Weight:
- 185.11
- MDL Number:
- MFCD00275565
- MOL File:
- 403-24-7.mol
- MSDS File:
- SDS
| Melting point | 170 °C |
|---|---|
| Boiling point | 352.5±27.0 °C(Predicted) |
| Density | 1.568±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 2.37±0.13(Predicted) |
| color | White to Light yellow |
| BRN | 2582091 |
| InChI | InChI=1S/C7H4FNO4/c8-6-3-4(9(12)13)1-2-5(6)7(10)11/h1-3H,(H,10,11) |
| InChIKey | MMWFMFZFCKADEL-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C([N+]([O-])=O)C=C1F |
| CAS DataBase Reference | 403-24-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-37/39-36/37/39-22 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
2-Fluoro-4-nitrobenzoic acid price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L446572 | 2-FLUORO-4-NITROBENZOIC ACID Aldrich | 403-24-7 | 250mg | $29.8 | 2024-03-01 | Buy |
| TCI Chemical | F0797 | 2-Fluoro-4-nitrobenzoic Acid >98.0%(GC)(T) | 403-24-7 | 5g | $66 | 2024-03-01 | Buy |
| TCI Chemical | F0797 | 2-Fluoro-4-nitrobenzoic Acid >98.0%(GC)(T) | 403-24-7 | 25g | $196 | 2024-03-01 | Buy |
| Alfa Aesar | L19770 | 2-Fluoro-4-nitrobenzoic acid, 98% | 403-24-7 | 1g | $81.65 | 2024-03-01 | Buy |
| Alfa Aesar | L19770 | 2-Fluoro-4-nitrobenzoic acid, 98% | 403-24-7 | 5g | $285.65 | 2024-03-01 | Buy |
2-Fluoro-4-nitrobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Synthesis
A mixture of 2-fluoro4-nitrotoluene (31.1 g, 0.2 mol), tetrabutylammonium bromide (3.2 g,0.01 mol), 1.0 L of 1N NaOH, and KMnO4 (20.0 g) was stirred at room temperature. After 10 min, the resulting mixture was heated to 95 °Cwith stirring. Additional 30.0 g portions of KMnO 4 were added after 2 h and 3 h. After stirring at 95 °C for an additional 10 h, the reaction mixture was cooled to room temperature and filtered through Celite to remove MnO2. The filtrate was acidified to pH 2 by adding concentrated hydrochloric acid. An off-white precipitate formed that was collected by vacuum filtration. The crude solid was dissolved in 300 mL of 1N aqueous NaOH, acidified to pH 2 using concentrated hydrochloric acid, and the mixture extracted with CH 2 Cl 2 (3 × 200 mL). The combined CH2 Cl 2extracts were washed with 0.1 N aqueous HCl (2 × 100 mL), dried over anhydrous Na2SO4, and concentrated in vacuo to afford 27.3 g (73.7%)of 2-fluoro-4-nitrobenzoic acid as a white crystalline solid, m.p. 174.5–176.0 °C (lit 7. m.p. 176–177 °C)[1].
References
[1] Defeng Xu, Zhiling Zhu, Xing Xu. “A Convenient Synthesis of 4-amino-2-fluoro-N-methyl-benzamide.” Journal of Chemical Research-s 17 1 (2013): 615–616.
2-Fluoro-4-nitrobenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | sales@fluoropharm.com | China | 1376 | 60 |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5790 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 | sales01@watsonbiotech.cn | China | 5821 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9206 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
View Lastest Price from 2-Fluoro-4-nitrobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | 2-Fluoro-4-nitrobenzoic acid
403-24-7
|
US $0.00-0.00 / kg | 1kg | 99% | 20MT | Watson Biotechnology Co.,Ltd | |
 |
2023-11-01 | 2-Fluoro-4-nitrobenzoic acid
403-24-7
|
US $0.00-0.00 / kg | 0.1kg | 99.0%min | 200kg | Hangzhou ICH Biofarm Co., Ltd | |
 |
2022-02-22 | 2-Fluoro-4 nitrobenzoic acid
403-24-7
|
US $0.00 / KG | 1KG | 98.0% | 100 tons | Honest Joy Holdings Limited
|
-
- 2-Fluoro-4-nitrobenzoic acid
403-24-7
- US $0.00-0.00 / kg
- 99%
- Watson Biotechnology Co.,Ltd
-
- 2-Fluoro-4-nitrobenzoic acid
403-24-7
- US $0.00-0.00 / kg
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- 2-Fluoro-4 nitrobenzoic acid
403-24-7
- US $0.00 / KG
- 98.0%
- Honest Joy Holdings Limited
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