ChemicalBook >> CAS DataBase List >>Gefitinib-d6
Gefitinib-d6
- CAS No.
- 1228664-49-0
- Chemical Name:
- Gefitinib-d6
- Synonyms
- Gefitinib-d6;[2H6]-Gefitinib;Hexadeuterated gefitinib;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
- CBNumber:
- CB12674404
- Molecular Formula:
- C22H24ClFN4O3
- Molecular Weight:
- 446.91
- MDL Number:
- MFCD21363632
- MOL File:
- 1228664-49-0.mol
Last updated:2024-07-02 08:55:00
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302+H312+H332-H315-H319 | |||||||||
Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501 | |||||||||
NFPA 704 |
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Gefitinib-d6 price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 22364 | Gefitinib-d6 ≥99% deuterated forms (d1-d6) | 1228664-49-0 | 500μg | $130 | 2024-03-01 | Buy |
Cayman Chemical | 22364 | Gefitinib-d6 ≥99% deuterated forms (d1-d6) | 1228664-49-0 | 1mg | $243 | 2024-03-01 | Buy |
TRC | G304008 | Gefitinib-d6 | 1228664-49-0 | 10mg | $1540 | 2021-12-16 | Buy |
TRC | G304008 | Gefitinib-d6 | 1228664-49-0 | 25mg | $3520 | 2021-12-16 | Buy |
AK Scientific | 3663DG | Gefitinib-d6 | 1228664-49-0 | 1mg | $370 | 2021-12-16 | Buy |
Gefitinib-d6 Chemical Properties,Uses,Production
Description
Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).
Uses
Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.
Gefitinib-d6 Preparation Products And Raw materials
Raw materials
Preparation Products
Gefitinib-d6 Suppliers
Global( 16)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-4000505016 13380397412 | 3001272453@qq.com | China | 5056 | 50 |
Nanjing XiZe Biotechnology CO., Ltd. | 025-66023220 0086-15250997978 | 1511893459@qq.com | China | 7851 | 55 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Cato Research Chemicals Inc. | 020-81215950 4000-868-328 | customer@uwalab.com | United States | 10413 | 58 |
Shanghai YuZn Pharm. Technology Co.,Ltd. | 15921286451; 15921286451 | 2010681527@qq.com | China | 5073 | 58 |
Shanghai isotope chemical co.,ltd | 021-021-51600108 13062666369 | sales@chinaisotope.com | China | 4274 | 58 |
Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5597 | 58 |
Shanghai Beiwanta Biotechnology Co., Ltd. | 021-67187366 19901745723 | info@bwtlab.com | China | 9261 | 58 |
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1of4
Gefitinib-d6
Hexadeuterated gefitinib
[2H6]-Gefitinib
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
1228664-49-0