ChemicalBook >> CAS DataBase List >>4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
- CAS No.
- 215307-86-1
- Chemical Name:
- 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
- Synonyms
- 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoate;Benzoic acid, 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-
- CBNumber:
- CB12750575
- Molecular Formula:
- C21H21NO4
- Molecular Weight:
- 351.4
- MDL Number:
- MFCD18384955
- MOL File:
- 215307-86-1.mol
Last updated:2023-06-30 15:45:59
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
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4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0286 | BMS 753 ≥98% (HPLC) | 215307-86-1 | 5mg | $55.2 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0286 | BMS 753 ≥98% (HPLC) | 215307-86-1 | 25mg | $510 | 2023-01-07 | Buy |
Cayman Chemical | 29493 | BMS 753 | 215307-86-1 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 29493 | BMS 753 | 215307-86-1 | 5mg | $93 | 2024-03-01 | Buy |
Cayman Chemical | 29493 | BMS 753 | 215307-86-1 | 10mg | $169 | 2024-03-01 | Buy |
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Chemical Properties,Uses,Production
Uses
BMS 753 is as been reported to be a RARα-selective agonist. Used to develop a series of small molecule inhibitors which affect specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease. This would aspire to reduce the attrition problem in drug discovery.
Biological Activity
BMS 753 is a subtype-selective retinoic acid receptor alpha (RARα) agonist with a Ki value of 2 nM for RARα.
in vitro
BMS 753 results in low levels of RARβ transcripts in WT cells, RARγ -/- , but not activates in RARa -/- cells.
target
RARα
|
storage
Store at RT
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Suppliers
Global( 23)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4197 | 55 | |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9863 | 58 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29795 | 68 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Suzhou Chenrui Biotechnology Co. LTD | 17625585511 | 1580084073@qq.com | China | 516 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Benzoic acid, 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoate
215307-86-1