ChemicalBook >> CAS DataBase List >>TH287 (hydrochloride)
TH287 (hydrochloride)
- CAS No.
- 1638211-05-8
- Chemical Name:
- TH287 (hydrochloride)
- Synonyms
- CS-2086;TH287 HCl
- CBNumber:
- CB13041470
- Molecular Formula:
- C11H11Cl3N4
- Molecular Weight:
- 305.59
- MDL Number:
- MFCD28127273
- MOL File:
- 1638211-05-8.mol
Last updated:2023-05-21 10:59:17
TH287 (hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Crysdot | CD31003098 | TH287 hydrochloride 98+% | 1638211-05-8 | 5mg | $52 | 2021-12-16 | Buy |
| Crysdot | CD31003098 | TH287 hydrochloride 98+% | 1638211-05-8 | 10mg | $70 | 2021-12-16 | Buy |
| DC Chemicals | DC24091 | TH287 hydrochloride >98% | 1638211-05-8 | 10mg | $96 | 2021-12-16 | Buy |
| Crysdot | CD31003098 | TH287 hydrochloride 98+% | 1638211-05-8 | 50mg | $281 | 2021-12-16 | Buy |
| DC Chemicals | DC24091 | TH287 hydrochloride >98% | 1638211-05-8 | 50mg | $384 | 2021-12-16 | Buy |
TH287 (hydrochloride) Chemical Properties,Uses,Production
Description
TH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.
References
[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.
TH287 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
TH287 (hydrochloride) Suppliers
Global( 15)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7846 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| Cckinase, Inc. | +1 (732)236-3202 | sales@cckinase.com | United States | 2738 | 58 |
TH287 HCl
CS-2086
1638211-05-8