ChemicalBook >> CAS DataBase List >>Maleimide-NH-PEG6-CH2CH2COOPFP Ester
Maleimide-NH-PEG6-CH2CH2COOPFP Ester
- CAS No.
- 1599432-34-4
- Chemical Name:
- Maleimide-NH-PEG6-CH2CH2COOPFP Ester
- Synonyms
- Mal-amido-PEG6-PFP Ester;Mal-NH-PEG6-CH2CH2COOPFP ester;Maleimide-NH-PEG6-CH2CH2COOPFP Ester;4,7,10,13,16,19-Hexaoxa-22-azapentacosanoic acid, 25-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-23-oxo-, 2,3,4,5,6-pentafluorophenyl ester
- CBNumber:
- CB13309451
- Molecular Formula:
- C28H35F5N2O11
- Molecular Weight:
- 670.58
- MDL Number:
- MFCD34470032
- MOL File:
- 1599432-34-4.mol
Last updated:2023-02-23 14:24:01
Maleimide-NH-PEG6-CH2CH2COOPFP Ester Chemical Properties,Uses,Production
Biological Activity
Mal-NH-PEG6-CH2CH2COOPFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Maleimide-NH-PEG6-CH2CH2COOPFP Ester Preparation Products And Raw materials
Raw materials
Preparation Products
Maleimide-NH-PEG6-CH2CH2COOPFP Ester Suppliers
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Maleimide-NH-PEG6-CH2CH2COOPFP Ester
Mal-NH-PEG6-CH2CH2COOPFP ester
4,7,10,13,16,19-Hexaoxa-22-azapentacosanoic acid, 25-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-23-oxo-, 2,3,4,5,6-pentafluorophenyl ester
Mal-amido-PEG6-PFP Ester
1599432-34-4