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7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol structure

CAS No.: 352693-80-2

Chemical Name:: 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

Synonyms: MMRi62;7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

CBNumber:: CB13604099

Molecular Formula:: C21H15Cl2N3O

Molecular Weight:: 396.2693

MDL Number:

MOL File:: 352693-80-2.mol

Last updated:2024-07-02 08:55:00

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7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol Properties

storage temp.	4°C, protect from light
solubility	DMSO : 62.5 mg/mL (157.72 mM; ultrasonic and warming and heat to 60°C)
form	Solid
color	White to off-white

7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol Chemical Properties,Uses,Production

Description

MMRi62 is an MDM4-degrader and apoptosis inducer in leukemia cells. MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status. MMRi62 effectively induced apoptosis in p53 mutant, multidrug-resistant leukemia cells and patient samples in addition to p53 wild-type cells. In contrast, MMRi67 as a RING heterodimer disruptor and an enzymatic inhibitor of the MDM2-MDM4 E3 complex lacked MDM4-degrader activity and failed to induce apoptosis in these cells.

7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol Preparation Products And Raw materials

Raw materials

Preparation Products

7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol Suppliers

Global( 13)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3717	55
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9874	58
Shanghai Yu Ben Biotechnology Co., Ltd.	15502154572	yuben012@sina.com	China	505	58
Hefei Mokai Pharmaceutical Technology Co., Ltd	18130062233	3362556465@qq.com	China	8000	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Aikon International Limited	18626450290	yftan@aikonchem.com	China	10718	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4455	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5595	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	021-59167510 18117107507	vip@med-life.cn	China	5014	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Tianjin Kailiqi Biotechnology Co., Ltd.	55
Shanghai Chaolan Chemical Technology Center	58
Shanghai Yu Ben Biotechnology Co., Ltd.	58
Hefei Mokai Pharmaceutical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
Aikon International Limited	58
Nantong QuanYi Biotechnology Co., Ltd	58
Nanjing Tengyi Biotechnology Co., Ltd	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	58

7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol MMRi62 352693-80-2