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ChemicalBook >> CAS DataBase List >>(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE

(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE

(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE Structure
(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE structure
CAS No.
167144-79-8
Chemical Name:
(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE
Synonyms
R-96544HCl;R-96544 HYDROCHLORIDE;R96544 hydrochloride,R 96544 hydrochloride;(3R,5R)-5-(2-(2-(3-methoxyphenethyl)phenoxy)ethyl)-1-methylpyrrolidin-3-ol;3-Pyrrolidinol, 5-[2-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]ethyl]-1-methyl-, (3R,5R)-;(2R,4R)-5-(2-(2-(2-(3-Methoxyphenyl)ethyl)phenoxy)ethyl)-1-methyl-3-pyrrolidinolhydrochloride;(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE
CBNumber:
CB1366589
Molecular Formula:
C22H29NO3
Molecular Weight:
355.47
MDL Number:
MFCD06407939
MOL File:
167144-79-8.mol
Last updated:2023-05-23 08:29:18
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(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE Properties

Boiling point 484.5±40.0 °C(Predicted)
Density 1.109±0.06 g/cm3(Predicted)
storage temp. Store at RT
solubility <39.19mg/ml in Water; <39.19mg/ml in DMSO
pka 14.87±0.40(Predicted)

(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 1742 R-96544hydrochloride ≥99%(HPLC) 167144-79-8 10 $193 2021-12-16 Buy
Tocris 1742 R-96544hydrochloride ≥99%(HPLC) 167144-79-8 50 $789 2021-12-16 Buy
Usbiological 256398 R-96544 hydrochloride 167144-79-8 10mg $446 2021-12-16 Buy
ApexBio Technology B6842 R-96544hydrochloride 167144-79-8 50mg $1189 2021-12-16 Buy
ApexBio Technology B6842 R-96544hydrochloride 167144-79-8 10mg $284 2021-12-16 Buy
Product number Packaging Price Buy
1742 10 $193 Buy
1742 50 $789 Buy
256398 10mg $446 Buy
B6842 50mg $1189 Buy
B6842 10mg $284 Buy

(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

R-96544 Hydrochloride is a the active form of a novel 5-HT2A receptor antagonist R-102444. It inhibits the platelet aggregation induced by serotonin (5-hydroxytryptamine, 5-HT).

Definition

ChEBI: (3R,5R)-5-[2-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]ethyl]-1-methyl-3-pyrrolidinol is a stilbenoid.

Biological Activity

Potent, selective 5-HT 2 receptor antagonist; displays some selectivity for 5-HT 2A receptors (K i = 1.6 nM). IC 50 values are 2.2, 310, 2400, 3700, > 5000 and > 5000 nM for 5-HT 2 , a 1 -adrenergic, D 2 dopamine, 5-HT 1 , 5-HT 3 and b-adrenergic receptors respectively. Inhibits 5-HT-induced platelet aggregation and pressor responses in vivo .

(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE synthesis

167145-84-8
167144-79-8
Synthesis of (3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE from (2R,4R)-ethyl 4-hydroxy-2-(2-(2-(3-methoxyphenethyl)phenoxy)ethyl)pyrrolidine-1-carboxylate

(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

(2R,4R)-ethyl 4-hydroxy-2-(2-(2-(3-methoxyphenethyl)phenoxy)ethyl)pyrrolidine-1-carboxylate (2R,4R)-ethyl 4-(benzyloxy)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate

Preparation Products

(3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19994 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44843 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
ApexBio Technology -- sales@apexbt.com United States 6254 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Labnetwork lnc. 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
EMMX Biotechnology LLC 60
Energy Chemical 58
TargetMol Chemicals Inc. 58
ApexBio Technology 58

167144-79-8((3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE)Related Search:

1-Methyl-3-pyrrolidinol (3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE
R-96544 HYDROCHLORIDE (3R,5R)-5-[2-[2-[2-(3-METHOXYPHENYL)ETHYL]PHENOXY]ETHYL]-1-METHYL-3-PYRROLIDINOL HYDROCHLORIDE (2R,4R)-5-(2-(2-(2-(3-Methoxyphenyl)ethyl)phenoxy)ethyl)-1-methyl-3-pyrrolidinolhydrochloride R-96544HCl (3R,5R)-5-(2-(2-(3-methoxyphenethyl)phenoxy)ethyl)-1-methylpyrrolidin-3-ol 3-Pyrrolidinol, 5-[2-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]ethyl]-1-methyl-, (3R,5R)- R96544 hydrochloride,R 96544 hydrochloride 167144-79-8 Serotonin receptor