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CLORGYLINE HYDROCHLORIDE

CLORGYLINE HYDROCHLORIDE Structure
CLORGYLINE HYDROCHLORIDE structure
CAS No.
17780-75-5
Chemical Name:
CLORGYLINE HYDROCHLORIDE
Synonyms
Clorgyline HCl;CLORGYLINE HYDROCHLORIDE;Clorgiline (hydrochloride);Clorgyline HCl (M&B 9302, MB9302);N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop;N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL;N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine;3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride;N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride
CBNumber:
CB1445257
Molecular Formula:
C13H16Cl3NO
Molecular Weight:
308.63
MDL Number:
MFCD00052012
MOL File:
17780-75-5.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
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CLORGYLINE HYDROCHLORIDE Properties

storage temp. 2-8°C
solubility ≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O
form A crystalline solid
color White to off-white
FDA UNII H38V165133

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H312+H332
Precautionary statements  P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P312
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  UI0675000
HazardClass  6.1(b)
PackingGroup  III
NFPA 704
0
3 0

CLORGYLINE HYDROCHLORIDE price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M3778 N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride ≥97% (GC) 17780-75-5 50mg $120 2024-03-01 Buy
Sigma-Aldrich M3778 N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride ≥97% (GC) 17780-75-5 100mg $204 2024-03-01 Buy
Cayman Chemical 15925 Clorgyline (hydrochloride) ≥98% 17780-75-5 10mg $32 2024-03-01 Buy
Cayman Chemical 15925 Clorgyline (hydrochloride) ≥98% 17780-75-5 25mg $56 2024-03-01 Buy
Sigma-Aldrich M3778 N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride ≥97% (GC) 17780-75-5 500mg $696 2024-03-01 Buy
Product number Packaging Price Buy
M3778 50mg $120 Buy
M3778 100mg $204 Buy
15925 10mg $32 Buy
15925 25mg $56 Buy
M3778 500mg $696 Buy

CLORGYLINE HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 μM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM). As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.

Uses

Antidepressant;Monoamine oxidase A inhibitor

Uses

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:

  • in MAO-A biochemical assay
  • to study its effects on the transit of serotonin (5-HT) in the human placenta explants
  • to study its effects on human prostate cancer cells

Biochem/physiol Actions

MAO-A inhibitor.

References

[1]. abdelhafez om, amin km, ali hi, et al. synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase a inhibitors. j med chem. 2012 dec 13;55(23):10424-36.
[2]. mazouz f, gueddari s, burstein c, et al. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3h)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type b inhibitors. j med chem. 1993 apr 30;36(9):1157-67.
[3]. garcia-miralles m, ooi j, ferrari bardile c, et al. treatment with the mao-a inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of huntington disease. exp neurol. 2016 apr;278:4-10.

CLORGYLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

CLORGYLINE HYDROCHLORIDE Suppliers

Global( 95)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30240 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38632 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58
TargetMol Chemicals Inc. 		58
LEAPCHEM CO., LTD. 		58

View Lastest Price from CLORGYLINE HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Clorgyline hydrochloride pictures 2024-11-19 Clorgyline hydrochloride
17780-75-5
 US $45.00-55.00 / mg 99.8% 10g TargetMol Chemicals Inc.
Clorgyline hydrochloride pictures 2024-11-19 Clorgyline hydrochloride
17780-75-5
 US $45.00-55.00 / mg 99.8% 10g TargetMol Chemicals Inc.

CLORGYLINE HYDROCHLORIDE Spectrum

CLORGYLINE HYDROCHLORIDE(17780-75-5)MS

17780-75-5(CLORGYLINE HYDROCHLORIDE)Related Search:

Quartz PROPARGYLAMINE [3-(2-CHLORO-PHENOXY)-PROPYL]-METHYL-AMINE [3-(4-CHLORO-PHENOXY)-PROPYL]-METHYL-AMINE 3-(4-chlorophenoxy)propan-1-amine
AKOS BBS-00007965 Propargylamine hydrochloride N,N-Dimethyl-3-phenoxypropylamine hydrochloride CLORGYLINE 3-phenoxy-1-propanamine
3-(4-CHLOROPHENOXY)PROPAN-1-AMINE HYDROCHLORIDE CLORGYLINE HYDROCHLORIDE 3-(2-chlorophenoxy)propan-1-amine N-methyl-N-(3-phenoxypropyl)amine

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CLORGYLINE HYDROCHLORIDE N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE 3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-aminhydrochloride n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propynylamine hydrochloride N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride,Clorgyline 2-Propyn-1-aMine, N-[3-(2,4-dichlorophenoxy)propyl]-N-Methyl-, hydrochloride 3-(2,4-dichlorophenoxy)-n-Methyl-n-prop-2-ynylpropan-1-aMine hydrochloride Clorgiline (hydrochloride) Clorgyline HCl N-(3-(2,4-dichlorophenoxy)propyl)-N-methylprop-2-yn-1-amine hydrochloride N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride >=97% (GC) Clorgyline HCl (M&B 9302, MB9302) 17780-75-5 C13H15Cl2NOHCl Enzyme Inhibitors Enzymes, Inhibitors, and Substrates Enzyme Inhibitors by Enzyme L to O Monoamine Oxidase-A Biochemicals and Reagents BioChemical