CFM 4
- CAS No.
- 331458-02-7
- Chemical Name:
- CFM 4
- Synonyms
- CFM 4;1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one;Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 1-[(2-chlorophenyl)methyl]-5'-phenyl-
- CBNumber:
- CB14718599
- Molecular Formula:
- C22H16ClN3OS
- Molecular Weight:
- 405.9
- MDL Number:
- MFCD01361024
- MOL File:
- 331458-02-7.mol
| Boiling point | 653.4±65.0 °C(Predicted) |
|---|---|
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (greater than 25 mg/ml) |
| form | solid |
| pka | 0.13±0.20(Predicted) |
| color | Tan |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
CFM 4 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 5144 | CFM4 ≥99%(HPLC) | 331458-02-7 | 10 | $156 | 2021-12-16 | Buy |
| Tocris | 5144 | CFM4 ≥99%(HPLC) | 331458-02-7 | 50 | $648 | 2021-12-16 | Buy |
| TRC | C291738 | CFM4 | 331458-02-7 | 5mg | $385 | 2021-12-16 | Buy |
| Usbiological | 254924 | CFM 4 | 331458-02-7 | 10mg | $452 | 2021-12-16 | Buy |
| ApexBio Technology | B7760 | CFM4 | 331458-02-7 | 10mg | $308 | 2021-12-16 | Buy |
CFM 4 Chemical Properties,Uses,Production
Description
CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM).1 Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of medulloblastoma cells2 and malignant pleural mesothelioma cells3.
References
1) Puliyappadamba et al. (2011), Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis; J. Biol. Chem. 286 38000 2) Ashour et al. (2013), CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth; PLoS ONE 8 e66733 3) Jamal et al. (2014), CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells; PLoS ONE 9 e89146
CFM 4 Preparation Products And Raw materials
Raw materials
Preparation Products
CFM 4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3717 | 55 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 48467 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |