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NUTLIN-3

NUTLIN-3 structure

CAS No.: 548472-68-0

Chemical Name:: NUTLIN-3

Synonyms: CS-390;NUTLIN-3;(?)-NUTLIN-3;Nutlin-3, >=98%;NUTLIN3;NUTLIN 3;Nutlin-3 ((±NUTLIN-3 (Free base);(±)-Nutlin-3, MDM2 antagonist;MDM2 Antagonist, Nutlin-3, Racemic;(+)-Nutlin-3, p53-MDM2 binding inhibitor

CBNumber:: CB5101900

Molecular Formula:: C30H30Cl2N4O4

Molecular Weight:: 581.49

MDL Number:: MFCD07784509

MOL File:: 548472-68-0.mol

MSDS File:: SDS

Last updated:2024-11-19 15:53:33

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NUTLIN-3 Properties

Melting point	>132oC (dec.)
Density	1.36±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: 20 mg/mL, soluble
form	solid
pka	14.35±0.20(Predicted)
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey	BDUHCSBCVGXTJM-UHFFFAOYSA-N
FDA UNII	53IA0V845C

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

NFPA 704

	0
2		0

NUTLIN-3 price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N6287	Nutlin-3 ≥98% (HPLC), powder	548472-68-0	1mg	$129	2024-03-01	Buy
Sigma-Aldrich	444143	MDM2 Antagonist, Nutlin-3, Racemic	548472-68-0	1mg	$144	2024-03-01	Buy
Cayman Chemical	10004372	(±)-Nutlin-3 ≥98%	548472-68-0	1mg	$37	2024-03-01	Buy
Cayman Chemical	10004372	(±)-Nutlin-3 ≥98%	548472-68-0	5mg	$109	2024-03-01	Buy
Sigma-Aldrich	N6287	Nutlin-3 ≥98% (HPLC), powder	548472-68-0	5mg	$442	2024-03-01	Buy

Product number	Packaging	Price	Buy
N6287	1mg	$129	Buy
444143	1mg	$144	Buy
10004372	1mg	$37	Buy
10004372	5mg	$109	Buy
N6287	5mg	$442	Buy

NUTLIN-3 Chemical Properties,Uses,Production

Description

(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 and its less active enantiomer (+)-nutlin-3 . In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.

Uses

(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.

Definition

ChEBI: 4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone is a stilbenoid.

Biochem/physiol Actions

Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.

storage

Store at -20°C

References

1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2; Science, 303 844 2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neurosci. Lett., 513 106 3) Manfe et al. (2012), MDM2 inhibitor nutlin-3 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487 4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859

NUTLIN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

NUTLIN-3 Suppliers

Global( 150)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	17982	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29810	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
Alfa Chemistry	58
LEAP CHEM CO., LTD.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

View Lastest Price from NUTLIN-3 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Nutlin-3 548472-68-0	US $54.00-126.00 / mg		99.89%	10g	TargetMol Chemicals Inc.
	2020-01-13	Nutlin (3) 548472-68-0	US $1.00 / g	1g	99%	1ton	Career Henan Chemical Co

Nutlin-3
548472-68-0
US $54.00-126.00 / mg
99.89%
TargetMol Chemicals Inc.

Nutlin (3)
548472-68-0
US $1.00 / g
99%
Career Henan Chemical Co

548472-68-0(NUTLIN-3)Related Search:

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Cantharidin 2-Ethoxybenzamidine hydrochloride 1-(2-METHOXYBENZYLAMINO)-2-(4-CHLOROPHENYL)ETHANE NUTLIN-3 2,4-DIMETHOXY-BENZAMIDINE

PIPERAZINE-1-CARBOXYLIC ACID DIETHYLAMIDE meso-1,2-Bis(4-chlorophenyl)ethylenediamine CHEMBRDG-BB 5543528 CHEMBRDG-BB 5570316 2,4-DIMETHOXY-BENZAMIDINE HCL

2-(4 5-DIHYDRO-1H-IMIDAZOL-2-YL)PHENOL

1of4

(+/-)-4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE NUTLIN-3 2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel- 4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel- 4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-Methoxy-phenyl)-4,5-dihydro-iMidazole-1-carbonyl]-piperazin-2-one Nutlin-3, >=98% NUTLIN-3 (Free base) 4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbony MDM2 Antagonist, Nutlin-3, Racemic MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem (?)-NUTLIN-3 Nutlin-3 ((± NUTLIN3;NUTLIN 3 CS-390 4-(cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one (±)-Nutlin-3, MDM2 antagonist (+)-Nutlin-3, p53-MDM2 binding inhibitor 548472-68-0 C30H30Cl2N4O4 Inhibitors