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9c(i472)

9c(i472) structure

CAS No.: 2349374-37-2

Chemical Name:: 9c(i472)

Synonyms: 9c(i472);15-LOX-1 inhibitor 1;6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-1H-indole-2-carboxylic acid, ethyl ester;1H-Indole-2-carboxylic acid, 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-, ethyl ester

CBNumber:: CB16197587

Molecular Formula:: C22H21ClN2O4

Molecular Weight:: 412.87

MDL Number:

MOL File:: 2349374-37-2.mol

Last updated:2024-07-02 08:55:01

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9c(i472) Properties

Boiling point	683.5±55.0 °C(Predicted)
Density	1.305±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: soluble; Methanol: slightly soluble
form	A crystalline solid
pka	13.41±0.30(Predicted)
color	Off-white to light yellow

9c(i472) Chemical Properties,Uses,Production

Description

9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC₅₀ = 0.19 μM).¹ It decreases LPS- and IFN-γ-induced NF-?B activity in RAW-Blue? cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM.

References

1. Guo, H., Verhoek, I.C., Prins, G.G.H., et al. Novel 15-lipoxygenase-1 inhibitor protects macrophages from lipopolysaccharide-induced cytotoxicity J. Med. Chem. 62(9),4624-4637(2019).

9c(i472) Preparation Products And Raw materials

Raw materials

Preparation Products

9c(i472) Suppliers

Global( 13)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9946	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	18779	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7979	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5597	58
Anqing YanZhi Pharma Discovery Co.,Ltd.	18055651951	2272561977@qq.com	China	322	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Aladdin Scientific	58
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Chaolan Chemical Technology Center	58
Shanghai Hongye Biotechnology Co. Ltd	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Yiyan Biotechnology Co. , Ltd.	58
Nanjing Tengyi Biotechnology Co., Ltd	58
Anqing YanZhi Pharma Discovery Co.,Ltd.	58

9c(i472) 15-LOX-1 inhibitor 1 1H-Indole-2-carboxylic acid, 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-, ethyl ester 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-1H-indole-2-carboxylic acid, ethyl ester 2349374-37-2