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9c(i472)

9c(i472) Structure
9c(i472) structure
CAS No.
2349374-37-2
Chemical Name:
9c(i472)
Synonyms
9c(i472);15-LOX-1 inhibitor 1;6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-1H-indole-2-carboxylic acid, ethyl ester;1H-Indole-2-carboxylic acid, 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-, ethyl ester
CBNumber:
CB16197587
Molecular Formula:
C22H21ClN2O4
Molecular Weight:
412.87
MDL Number:
MOL File:
2349374-37-2.mol
Last updated:2024-10-28 16:48:35
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9c(i472) Properties

Boiling point 683.5±55.0 °C(Predicted)
Density 1.305±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: soluble; Methanol: slightly soluble
form A crystalline solid
pka 13.41±0.30(Predicted)
color Off-white to light yellow

9c(i472) Chemical Properties,Uses,Production

Description

9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF-?B activity in RAW-Blue? cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM.

References

1. Guo, H., Verhoek, I.C., Prins, G.G.H., et al. Novel 15-lipoxygenase-1 inhibitor protects macrophages from lipopolysaccharide-induced cytotoxicity J. Med. Chem. 62(9),4624-4637(2019).

9c(i472) Preparation Products And Raw materials

Raw materials

Preparation Products

9c(i472) Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
ATK CHEMICAL COMPANY LIMITED 021-51619050 13301662590 mandy@atkchemical.com China 10197 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24644 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7978 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 6828 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
ATK CHEMICAL COMPANY LIMITED 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Nanjing Tengyi Biotechnology Co., Ltd 58

View Lastest Price from 9c(i472) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
15-LOX-1 inhibitor 1 pictures 2024-10-28 15-LOX-1 inhibitor 1
2349374-37-2
 US $158.00-490.00 / mg 10g TargetMol Chemicals Inc.
9c(i472) 15-LOX-1 inhibitor 1 1H-Indole-2-carboxylic acid, 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-, ethyl ester 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-1H-indole-2-carboxylic acid, ethyl ester 2349374-37-2