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IM-93

IM-93 Structure
IM-93 structure
CAS No.
1173657-73-2
Chemical Name:
IM-93
Synonyms
IM-93;3-[[3-(dimethylamino)propyl]amino]-1-(1-methylethyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[[3-(dimethylamino)propyl]amino]-1-(1-methylethyl)-4-(1-methyl-1H-indol-3-yl)-
CBNumber:
CB16197688
Molecular Formula:
C21H28N4O2
Molecular Weight:
368.47
MDL Number:
MOL File:
1173657-73-2.mol
Last updated:2023-05-21 10:59:17
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IM-93 Properties

Boiling point 540.2±50.0 °C(Predicted)
Density 1.17±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 20mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL; Ethanol: 1mg/mL
form A crystalline solid
pka 9.48±0.28(Predicted)

IM-93 Chemical Properties,Uses,Production

Description

IM-93 is a dual inhibitor of ferroptosis and NETosis.1 It inhibits tert-butyl hydroperoxide- and erastin-induced ferroptosis in NIH3T3 cells (IC50s =1.8 and 1.9 nM, respectively), as well as decreases NETosis and lipid peroxidation induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human peripheral blood neutrophils when used at concentrations ranging from 1.6 to 25 μM. IM-93 also inhibits hydrogen peroxide-induced necrosis in HL-60 cells (IC50 = 0.45 μM), but has no effect on necroptosis induced by Fas ligand in combination with Z-VAD-FMK and cycloheximide in Jurkat cells or pyroptosis induced by S. aureus and P. aeruginosa in THP-1 cells when used at a concentration of 25 μM.

References

1. Dodo, K., Kuboki, E., Shimizu, T., et al. Development of a water-soluble indolylmaleimide derivative IM-93 showing dual inhibition of ferroptosis and NETosis ACS Med. Chem. Lett. 10(9),1272-1278(2019).

IM-93 Preparation Products And Raw materials

Raw materials

Preparation Products

IM-93 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5597 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11975 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19696 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
IM-93 1H-Pyrrole-2,5-dione, 3-[[3-(dimethylamino)propyl]amino]-1-(1-methylethyl)-4-(1-methyl-1H-indol-3-yl)- 3-[[3-(dimethylamino)propyl]amino]-1-(1-methylethyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 1173657-73-2