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Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester

Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester Structure
Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester structure
CAS No.
145119-18-2
Chemical Name:
Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester
Synonyms
Boc-NH-PEG1-C2-Boc;N-Boc-PEG-t-butyl ester;t-Butyl 3-(2-N-Boc-aminoethoxy)propanoate;tert-butyl 3-(2-(tert-butoxycarbonyl)ethoxy)propanoate;Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester
CBNumber:
CB18183283
Molecular Formula:
C14H27NO5
Molecular Weight:
289.37
MDL Number:
MFCD29764404
MOL File:
145119-18-2.mol
Last updated:2024-03-25 20:41:16
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Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester Properties

Boiling point 384.2±22.0 °C(Predicted)
Density 1.026±0.06 g/cm3(Predicted)
pka 12.22±0.46(Predicted)

Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester Chemical Properties,Uses,Production

Biological Activity

N-Boc-PEG-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068 +86-15680926068 1924344760@confluore.cn China 2996 58
Sci General Material & Chemical Ltd 21-58388037 13472507714 1589045147@qq.com China 746 55
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4825 58
Shanghai Aizikang Pharmaceutical Research Co., Ltd 18721109360 306685371@qq.com China 1900 58
Supplier Advantage
Xian confluore Biological Technology Co., Ltd. 		58
Sci General Material & Chemical Ltd 55
Xi'an Confluore Biological Technology Co., Ltd. 58
Shanghai Aizikang Pharmaceutical Research Co., Ltd 58

View Lastest Price from Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-NH-PEG1-C2-Boc pictures 2024-03-25 Boc-NH-PEG1-C2-Boc
145119-18-2
 US $0.00 / g 1g >98.00% 1g Xian confluore Biological Technology Co., Ltd.
  • Boc-NH-PEG1-C2-Boc pictures
  • Boc-NH-PEG1-C2-Boc
    145119-18-2
  • US $0.00 / g
  • >98.00%
  • Xian confluore Biological Technology Co., Ltd.
Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester t-Butyl 3-(2-N-Boc-aminoethoxy)propanoate N-Boc-PEG-t-butyl ester Boc-NH-PEG1-C2-Boc tert-butyl 3-(2-(tert-butoxycarbonyl)ethoxy)propanoate 145119-18-2