Glibornuride
- CAS No.
- 26944-48-9
- Chemical Name:
- Glibornuride
- Synonyms
- N-((3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methylbenzenesulfonamide;Glitrim;Ro-6-4563;Glibornurid;Glibornuride;Glibornuride USP/EP/BP;Glibornuride (Mixture of Diastereomers);Glibornuride Solution in Acetonitrile/Water, 1000μg/mL;1-[p-Tolylsulfonyl]-3-[2-endo-hydroxy-3-endo-D-bornyl] urea;1-(3-hydroxy-4,7,7-trimethyl-norbornan-2-yl)-3-(4-methylphenyl)sulfonyl-urea
- CBNumber:
- CB1875191
- Molecular Formula:
- C18H26N2O4S
- Molecular Weight:
- 366.47504
- MDL Number:
- MFCD00869202
- MOL File:
- 26944-48-9.mol
Melting point | 192-195° (ethanol-water); also reported as 195-198° |
---|---|
alpha | D +63.8° (ethanol) |
Density | 1.1793 (rough estimate) |
refractive index | 1.6930 (estimate) |
storage temp. | Store at -20°C |
solubility | DMSO : 250 mg/mL (682.17 mM; Need ultrasonic) |
form | Solid |
pka | 5.20±0.10(Predicted) |
color | White to off-white |
FDA UNII | VP83E7434R |
ATC code | A10BB04 |
Glibornuride price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | G409700 | Glibornuride | 26944-48-9 | 10mg | $240 | 2021-12-16 | Buy |
Usbiological | 164299 | Glibornuride | 26944-48-9 | 2.5mg | $355 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0010408 | GLIBORNURIDE 95.00% | 26944-48-9 | 1MG | $750.75 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0010408 | GLIBORNURIDE 95.00% | 26944-48-9 | 5MG | $1963.5 | 2021-12-16 | Buy |
AvaChem | 3155 | Glibornuride | 26944-48-9 | 25mg | $390 | 2021-12-16 | Buy |
Glibornuride Chemical Properties,Uses,Production
Originator
Glutril,Roche,W. Germany,1972
Uses
Glibornuride has been shown to antagonize the relaxant response to the K+ channel opener cromakalim and produce airway smooth muscle relaxation. Glibornuride is associated with lactic acidosis and hypoglycemia in patients with type 2 diabetes melitus.
Definition
ChEBI: Glibornuride is a monoterpenoid.
Manufacturing Process
2.1 grams of 3-endo-aminoborneol hydrochloride and 2.4 grams of O-methylN-p-toluene-sulfonyl-urea are heated at 125°C for 3 hours with 2 ml of dimethylformamide. After cooling, the reaction mixture is stirred with 100 ml of water for 10 minutes, while a pH of 3.5 is maintained by the addition of a few drops of dilute hydrochloric acid. The precipitate is removed by filtration, washed with water and suspended in 100 ml of water. The suspension is dissolved by the addition of 20 ml of 1 N caustic soda. The alkaline solution is extracted with ether, acidified with dilute hydrochloric acid and filtered. The precipitate is washed with water and recrystallized from alcohol/water to yield 1-(p-toluene-sulfonyl)-3-(2-endo-hydroxy-3-endo-bornyl)-urea having a melting point of 193° to 195°C.
brand name
Glutril (Hoffmann-LaRoche).
Therapeutic Function
Oral hypoglycemic
Glibornuride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8853 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94658 | 76 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |